62498-69-5Relevant articles and documents
Improved syntheses of N-desmethylcitalopram and N,N-didesmethylcitalopram
Jin, Chunyang,Boldt, Karl G.,Rehder, Kenneth S.,Brine, George A.
, p. 901 - 908 (2007/10/03)
An improved and efficient synthesis of N-desmethylcitalopram (2) and N,N-didesmethylcitalopram (3) is presented. The method involved N-demethylation of citalopram (1) using 1-chloroethyl chloroformate to give 2 in 87% yield. Synthesis of 3 was accomplished by alkylation of 8 with 1-(3-bromopropyl)-2,2,5, 5-tetramethyl-1-aza-2,5-disilacyclopentane (9). Copyright Taylor & Francis Group, LLC.
PREPARATION OF ESCITALOPRAM
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Page/Page column 26-27, (2008/06/13)
Enantiomerically enriched citalopram is prepared by methylating enantiomerically enriched didesmethylcitalopram, obtained by directly resolving racemic didesmethylcitalopram using a chiral acid.