625-37-6

Basic information

• Product Name: Crotonamide
• Synonyms: 2-Butenamide,(E)-;Crotonamide, (E)- (8CI);(E)-2-Butenamide;Ethylene,1-(aminocarbonyl)-2-methyl-, trans-;NSC 11802;trans-2-Butenamide;trans-Crotonamide
• CAS NO: 625-37-6
• Molecular Formula: C₄H₇NO
• Molecular Weight: 85.1045
• Mol File: 625-37-6.mol
• Article Data: 9

Chemical Properties

• Boiling Point: 218.7 °C at 760 mmHg
• Flash Point: 86 °C
• Appearance: /
• Density: 0.956 g/cm³
• CAS DataBase Reference: Crotonamide(CAS DataBase Reference)
• NIST Chemistry Reference: Crotonamide(625-37-6)
• EPA Substance Registry System: Crotonamide(625-37-6)

Safety Data

• Hazardous Substances Data: 625-37-6(Hazardous Substances Data)

Usage

General Description

Crotonamide, also known as but-2-enamide, is a chemical compound with the molecular formula C4H7NO. It is an amide derivative of crotonic acid and is commonly used as a starting material in the synthesis of various pharmaceuticals and organic compounds. Crotonamide is a colorless to pale yellow liquid with a pungent odor, and it is insoluble in water but soluble in organic solvents. It is considered to be a potentially hazardous substance and should be handled and stored with care. Crotonamide has been studied for its potential applications in various fields, including medicine, agriculture, and industry.

Upstream product

• 4786-20-3 but-2-enenitrile 
• 1190-76-7 (Z)-2-butenenitrile 
• 28446-58-4 but-3-enamide 
• 7664-93-9 sulfuric acid 
• 114959-87-4 (+/-)-erythro-2,3-dibromo-butyrohydroxamic acid 
• 107-93-7 (E)-but-2-enoic acid 
• 110-89-4 piperidine 
• 56105-19-2 2-cyclopropylacetaldehyde 
• 107-91-5 cyanoacetic acid amide 
• 4786-20-3 crotononitrile 
• 17858-43-4 3-bromo-butyric acid amide 
• 107-05-1 3-chloroprop-1-ene 
• 31110-30-2 (Z)-but-2-enamide 
• 7553-56-2 iodine 

Downstream Products

• 4786-20-3 but-2-enenitrile 
• 31110-30-2 (Z)-but-2-enamide 
• 769065-62-5 3-Dimethylamino-buttersaeureamid 
• 393820-65-0 (R)-3-phenylbutyramide 
• 772-13-4 3-phenylbutanonamide 
• 943900-59-2 (2E)-N-(2-acetylphenyl)but-2-enamide 
• 89232-30-4 (2E)-N-benzylbut-2-enamide 
• 1113-58-2 beta-hydroxybutyramide 
• 73817-94-4 N-ethyl iodoacetamide 

Relevant articles and documents

A Brevibacterium process for synthesizing amide

The invention discloses a method for synthesizing amide through nitrile hydrolysis. The method comprises the following steps: adding nitrile, acetaldoxime, water, a water-soluble rhodium complex to a reaction vessel, and cooling to room temperature after reaction of a reaction mixture for several hours at the temperature of 50-80 DEG C; and adding ethyl acetate for extraction so as to obtain an organic layer, and carrying out rotary evaporation to remove a solvent, thus obtaining a target product. Compared with a method for synthesizing amide through nitrile hydrolysis by using oxime as a water source in a transition metal catalysis process, the method has the advantages that a used catalyst is low in loading and does not contain a phosphine ligand seriously polluting environments, synthesis can be performed in air, and nitrogen protection is not needed; and therefore, the method meets the green chemistry requirements and has a wide development prospect.

Superacidic activation of α,β-unsaturated amides and their electrophilic reactions

The electrophilic reactivity of α,β-unsaturated amides towards weak nucleophiles such as arenes and cyclohexane, initiated either with triflic acid (CF3SO3H) or with excess AlCl3, has been studied. The amides generally condense readily with aromatics in the presence of AlCl3 to give 3-arylpropionamides and related compounds in excellent yields, while some amides also undergo selective ionic hydrogenation with cyclohexane to give saturated amides. The proposed mechanism of these reactions involves dicationic intermediates (superelectrophiles). The direct observation of a dicationic species (by low-temperature NMR) is reported. Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2004.

TREATMENT OF PLATELET DERIVED GROWTH FACTOR RELATED DISORDERS SUCH AS CANCERS

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