625079-04-1Relevant articles and documents
Highly diastereoselective oxy-Michael additions of enantiopure δ-lactol anions to nitroalkenes: Asymmetric synthesis of 1,2-amino alcohols
Adderley, Nicola J.,Buchanan, David J.,Dixon, Darren J.,Laine, Dramane I.
, p. 4241 - 4244 (2003)
The "naked" alkoxide 1 of (S)-6-methyl-δ-lactol acts as an excellent chiral hydroxide equivalent in highly diastereoselective oxy-Michael additions to nitroalkenes (see scheme). The excellent stereoinduction arises from what becomes a superb protecting gr