625446-22-2

Basic information

• Product Name: 4-BROMO-2-FLUOROACETOPHENONE
• Synonyms: 1-Acetyl-4-bromo-2-fluorobenzene;1-(4-Bromo-2-fluorophenyl)ethan-1-one;1-(4-broMophenyl)-2-fluoroethan-1-one;Ethanone, 1-(4-broMo-2-fluorophenyl)-;4'-BROMO-2'-FLUOROACETOPHENONE;4-BROMO-2-FLUOROACETOPHENONE;4-Bromo-2-fluoroacetophenone/2-Fluoro-4-bromoacetophenone;4'-Bromo-2'-fluoroacetophenone 98%
• CAS NO: 625446-22-2
• Molecular Formula: C₈H₆BrFO
• Molecular Weight: 217.04
• Product Categories: Fluorine series;Adehydes, Acetals & Ketones;Bromine Compounds;Fluorine Compounds
• Mol File: 625446-22-2.mol
• Article Data: 20

Chemical Properties

• Melting Point: 23 °C
• Boiling Point: 256.305 °C at 760 mmHg
• Flash Point: 108.81 °C
• Appearance: /Solid
• Density: 1.535 g/cm³
• Vapor Pressure: 0.016mmHg at 25°C
• Refractive Index: 1.534
• Storage Temp.: Sealed in dry,Room Temperature
• Solubility: Acetonitrile (Slightly), Chloroform (Slightly)
• CAS DataBase Reference: 4-BROMO-2-FLUOROACETOPHENONE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-BROMO-2-FLUOROACETOPHENONE(625446-22-2)
• EPA Substance Registry System: 4-BROMO-2-FLUOROACETOPHENONE(625446-22-2)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38-36
• Safety Statements: 26-36/37/39
• Hazardous Substances Data: 625446-22-2(Hazardous Substances Data)

Usage

General Description

4-Bromo-2-fluoroacetophenone is a chemical compound with the molecular formula C8H6BrFO. It belongs to the category of organic compounds called benzoyl derivatives. 4-BROMO-2-FLUOROACETOPHENONE is characterized by a benzene ring, bromine and fluorine atoms and a ketone group. It is a highly reactive substance that undergoes various chemical transformations, including reactions with nucleophiles and bases. It is commonly used in the synthesis of various organic compounds, including pharmaceuticals and dyes. It is also used as a starting material in the preparation of other specialized chemicals. Its physical properties include a relatively high melting and boiling point, and it is normally found as a white solid at room temperature.

InChI:InChI=1/C8H6BrFO/c1-5(11)7-3-2-6(9)4-8(7)10/h2-4H,1H3

Upstream product

• 75-16-1 methylmagnesium bromide 
• 801303-33-3 4-bromo-2-fluoro-N-methoxy-N-methylbenzamide 
• 302912-33-0 4-bromo-1-ethynyl-2-fluorobenzene 
• 99-90-1 para-bromoacetophenone 
• 74-88-4 methyl iodide 
• 57848-46-1 4-bromo-2-fluorobenzaldehyde 
• 112704-79-7 2-fluoro-4-bromobenzoic acid 
• 676-58-4 methylmagnesium chloride 
• 353282-88-9 1-(4-bromo-2-fluorophenyl)ethanol 

Downstream Products

• 1007346-31-7 C₁₅H₁₁BrFN₃ 
• 1345404-73-0 3-methyl-1-phenyl-1H-indazol-6-ylamine hydrochloride 
• 1007885-10-0 C₁₈H₂₁BrFNO₅ 
• 1363139-88-1 2-[(8S)-3-[3-methoxy-4-(2-methyl-1,3-oxazol-5-yl)phenyl]-8-(3,4,5-trifluorophenoxy)-5,6,7,8-tetrahydro[1,2,4]triazolo[4,3-a]pyridin-8-yl]propan-2-ol 
• 1363143-27-4 ethyl 8-[6-(2-ethoxy-2-oxoethyl)-2,3,4-trifluorophenoxy]-3-[3-methoxy-4-(2-methyl-1,3-oxazol-5-yl)phenyl]-5,6,7,8-tetrahydro[1,2,4]triazolo[4,3-a]pyridine-8-carboxylate 
• 1363149-15-8 ethyl 2-azido-7-(3-methoxy-4-(2-methyloxazol-5-yl)phenyl)hept-6-ynoate 
• 1363148-80-4 ethyl 3-[3-methoxy-4-(2-methyl-1,3-oxazol-5-yl)phenyl]-8-[(3,4,5-trifluorophenyl)amino]-5,6,7,8-tetrahydro[1,2,4]triazolo[4,3-a]pyridine-8-carboxylate 
• 1363147-16-3 ethyl 8-(3,5-difluorophenoxy)-3-[3-methoxy-4-(2-methyl-1,3-oxazol-5-yl)phenyl]-5,6,7,8-tetrahydro[1,2,4]triazolo[4,3-a]pyridine-8-carboxylate 
• 1363147-11-8 ethyl 8-[(3,4-difluorophenyl)sulfanyl]-3-[3-methoxy-4-(2-methyl-1,3-oxazol-5-yl)phenyl]-5,6,7,8-tetrahydro[1,2,4]triazolo[4,3-a]pyridine-8-carboxylate 
• 1363146-79-5 ethyl 8-[(4-chlorophenoxy)methyl]-3-[3-methoxy-4-(2-methyl-1,3-oxazol-5-yl)phenyl]-5,6,7,8-tetrahydro[1,2,4]triazolo[4,3-a]pyridine-8-carboxylate 
• 1363140-04-8 2-{8-[(4-chlorophenoxy)methyl]-3-[3-methoxy-4-(2-methyl-1,3-oxazol-5-yl)phenyl]-5,6,7,8-tetrahydro[1,2,4]triazolo[4,3-a]pyridin-8-yl}propan-2-ol 
• 1363146-74-0 ethyl (8R)-3-[3-methoxy-4-(2-methyl-1,3-oxazol-5-yl)phenyl]-8-(3,4,5-trifluorophenoxy)-5,6,7,8-tetrahydro[1,2,4]triazolo[4,3-a]pyridine-8-carboxylate 
• 1363139-60-9 3-{8-(3,4-difluorophenoxy)-3-[3-methoxy-4-(2-methyl-1,3-oxazol-5-yl)phenyl]-5,6,7,8-tetrahydro[1,2,4]triazolo[4,3-a]pyridin-8-yl}propan-3-ol 
• 1363139-55-2 3-{8-(3,4-difluorophenoxy)-3-[3-methoxy-4-(2-methyl-1,3-oxazol-5-yl)phenyl]-5,6,7,8-tetrahydro[1,2,4]triazolo[4,3-a]pyridin-8-yl}pentan-3-ol 

Relevant articles and documents

Pd-Catalysed direct C(sp2)-H fluorination of aromatic ketones: Concise access to anacetrapib

The Pd-cataylsed direct ortho-C(sp2)-H fluorination of aromatic ketones has been developed for the first time. The reaction features good regioselectivity and simple operations, constituting an alternative shortcut to access fluorinated ketones. A concise synthesis of anacetrapib has also been achieved by using late-stage C-H fluorination as a key step.

Discovery, Structure-Activity Relationship, and Biological Characterization of a Novel Series of 6-((1 H-Pyrazolo[4,3- b]pyridin-3-yl)amino)-benzo[ d]isothiazole-3-carboxamides as Positive Allosteric Modulators of the Metabotropic Glutamate Receptor 4 (mG

This work describes the discovery and characterization of novel 6-(1H-pyrazolo[4,3-b]pyridin-3-yl)amino-benzo[d]isothiazole-3-carboxamides as mGlu4 PAMs. This scaffold provides improved metabolic clearance and CYP1A2 profiles compared to previo

HETEROCYCLIC COMPOUNDS AS CALCIUM SENSING RECEPTOR MODULATORS FOR THE TREATMENT OF HYPERPARATHYROIDISM, CHRONIC RENAL FAILURE AND CHRONIC KIDNEY DISEASE

The invention relates to heterocyclic compounds of Formula (I) and their pharmaceutically acceptable salts, wherein the substituents are as described herein, and their pharmaceutical compositions for use in medicine for the treatment of diseases or disorders associated with the modulation of calcium sensing receptor modulators (CaSR), like e.g. hyperparathyroidism, chronic renal failure and chronic kidney disease and their complications.