625853-22-7

Basic information

• Product Name: phenyl (S)-N-[3-acetoxy-3-(thien-2-yl)propyl]-N-methylcarbamate
• Synonyms: phenyl (S)-N-[3-acetoxy-3-(thien-2-yl)propyl]-N-methylcarbamate
• CAS NO: 625853-22-7
• Molecular Weight: 333.408
• Mol File: 625853-22-7.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: phenyl (S)-N-[3-acetoxy-3-(thien-2-yl)propyl]-N-methylcarbamate(CAS DataBase Reference)
• NIST Chemistry Reference: phenyl (S)-N-[3-acetoxy-3-(thien-2-yl)propyl]-N-methylcarbamate(625853-22-7)
• EPA Substance Registry System: phenyl (S)-N-[3-acetoxy-3-(thien-2-yl)propyl]-N-methylcarbamate(625853-22-7)

Safety Data

• Hazardous Substances Data: 625853-22-7(Hazardous Substances Data)

Upstream product

• 1885-14-9 phenyl chloroformate 
• 132335-44-5 (S)-3-dimethylamino-1-(2-thienyl)propan-1-ol 

Downstream Products

• 116539-55-0 (S)-3-methylamino-1-(2-thienyl)-1-propanol 

Relevant articles and documents

(S)- (-) - 3 - methylamino - 1 - (2 - thienyl) - 1 - propanol synthetic method

The present invention relates to a method for preparing (S)-(-)-3-methylamino-1-(2-thienyl)-1-propanol with high purity. The method comprises: taking the (S)-(-)-3-dimethylamino-1-(2-thienyl)-1-propanol as an starting material; in the presence of an organic solvent, protecting hydroxyl by a hydroxy protecting agent, then carrying out a demethylation reaction; and finally, carrying out a hydroxyl de-protection reaction in a strong alkaline environment in the presence of a hydroxyl de-protection agent, thereby obtaining a target product. According to the synthetic method, the (S)-(-)-3-methylamino-1-(2-thienyl)-1-propanol is over 99% in purity and ee value, and is over 80% in the yield, and the method is suitable for industrial production.