62620-71-7

Basic information

• Product Name: 6-(Trifluoromethyl)-2,3,4-trihydronaphthalen-1-one
• Synonyms: 6-(Trifluoromethyl)-2,3,4-trihydronaphthalen-1-one;6-(trifluoroMethyl)-3,4-dihydro-2H-naphthalen-1-one;6-(TRIFLUOROMETHYL)-3,4-DIHYDRONAPHTHALEN-1(2H)-ONE;1(2H)-Naphthalenone,3,4-dihydro-6-(trifluoromethyl)-
• CAS NO: 62620-71-7
• Molecular Formula: C11H9 F3 O
• Molecular Weight: 214.18
• Mol File: 62620-71-7.mol
• Article Data: 7

Chemical Properties

• Appearance: /
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• CAS DataBase Reference: 6-(Trifluoromethyl)-2,3,4-trihydronaphthalen-1-one(CAS DataBase Reference)
• NIST Chemistry Reference: 6-(Trifluoromethyl)-2,3,4-trihydronaphthalen-1-one(62620-71-7)
• EPA Substance Registry System: 6-(Trifluoromethyl)-2,3,4-trihydronaphthalen-1-one(62620-71-7)

Safety Data

• Hazardous Substances Data: 62620-71-7(Hazardous Substances Data)

Usage

Uses

6-Trifluoromethyltetralin-1-one is derived from 4-Bromobenzotrifluoride (B680525), which is an aromatic compound that is used as a reagent to synthesize Bergenin (B318650), a compound that originates in Mallotus japonicus that exhibits hepatoprotective and antioxidant effects. 4-Bromobenzotrifluoride is also used as a reagent to prepare (±)-Preclamol, a partial dopamine D2 agonist that is used to treat Parkinson’s disease.

Upstream product

• 88699-88-1 5-oxo-5-(4-(trifluoromethyl)phenyl)pentanoic acid 
• 402-43-7 p-trifluoromethylphenyl bromide 
• 29480-10-2 1-(4-(trifluoromethyl)phenyl)cyclobutan-1-ol 
• 145485-43-4 4-(3-(trifluoromethyl)phenyl)butanoic acid 

Relevant articles and documents

Decarboxylative Intramolecular Arene Alkylation Using N-(Acyloxy)phthalimides, an Organic Photocatalyst, and Visible Light

An intramolecular arene alkylation reaction has been developed using the organic photocatalyst 4CzIPN, visible light, and N-(acyloxy)phthalimides as radical precursors. Reaction conditions were optimized via high-throughput experimentation, and electron-rich and electron-deficient arenes and heteroarenes are viable reaction substrates. This reaction enables access to a diverse set of fused, partially saturated cores which are of high interest in synthetic and medicinal chemistry.

A rapid method for open-loop/oxidation based on substituted cyclobutanol cyclization reaction preparation Tetralone derivatives (by machine translation)

The invention discloses a method for quickly based on substituted cyclobutanol oxidation open-loop/cyclization reaction preparation Tetralone derivatives of the method, the method is that the aryl substituted cyclobutanol cerium amine in the nitric acid oxidation of a pot of reaction under the action of the generating Tetralone derivatives; this method has the advantages of fast response (30 seconds in the completion of the reaction), the operation is simple (the open reaction), mild reaction conditions, one-step reaction, does not need to use noble metal catalytic, the yield is high, can be expands the quantity reaction and the like, overcome in the prior art long reaction time, requires the use of a noble metal catalyst, more reaction steps, more byproducts and the like. (by machine translation)

Tandem Oxidative Ring-Opening/Cyclization Reaction in Seconds in Open Atmosphere for the Synthesis of 1-Tetralones in Water-Acetonitrile

A mild and practical tandem oxidative ring-opening/cyclization reaction mediated by Ce4+ for the synthesis of 1-tetralones is presented. This rapid transformation was completed within 30 s and conducted in an open reactor at 0 °C in a water-acetonitrile mixture. Various cyclobutanol derivatives are transformed into desired products in good to high yields, and this reaction can be easily scaled up to the gram scale.