626248-56-4

Basic information

• Product Name: 3-(2H-1,2,3-Trizazol-2-yl)aniline
• Synonyms: 3-(2H-1,2,3-Trizazol-2-yl)aniline;3-(2H-1,2,3-Triazol-2-yl)aniline;3-(2H-1,2,3-triazol-2-yl)benzenaMine;3-(2H-1,2,3-Triazol-2-yl)
• CAS NO: 626248-56-4
• Molecular Formula: C₈H₈N₄
• Molecular Weight: 160.17592
• Mol File: 626248-56-4.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 380.9±44.0 °C(Predicted)
• Appearance: /
• Density: 1.32
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• PKA: 3.44±0.10(Predicted)
• CAS DataBase Reference: 3-(2H-1,2,3-Trizazol-2-yl)aniline(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(2H-1,2,3-Trizazol-2-yl)aniline(626248-56-4)
• EPA Substance Registry System: 3-(2H-1,2,3-Trizazol-2-yl)aniline(626248-56-4)

Safety Data

• Hazardous Substances Data: 626248-56-4(Hazardous Substances Data)

Usage

General Description

3-(2H-1,2,3-Trizazol-2-yl)aniline is a chemical compound with the molecular formula C6H6N6. It is a derivative of aniline that contains a 1,2,3-triazole ring. 3-(2H-1,2,3-Trizazol-2-yl)aniline is commonly used as a building block in organic synthesis and is often employed in pharmaceutical and agrochemical research. It exhibits a range of interesting biological properties, including antitumor and antimicrobial activities, making it a valuable tool in medicinal chemistry. Additionally, 3-(2H-1,2,3-Trizazol-2-yl)aniline has potential applications in materials science, particularly in the development of functionalized polymers and coordination compounds.

InChI:InChI=1S/C8H8N4/c9-7-2-1-3-8(6-7)12-10-4-5-11-12/h1-6H,9H2

Upstream product

• 288-36-8 1,2,3-triazole 
• 626-01-7 3-Iodoaniline 
• 342623-98-7 2-(3-nitrophenyl)-2H-1,2,3-triazole 
• 402-67-5 3-fluoro-1-nitrobenzene 
• 51039-49-7 2-phenyl-2H-[1,2,3]triazole 

Downstream Products

• 1370261-95-2 tert-butyl (1S,2R)-2-(4-(3-(2H-1,2,3-triazol-2-yl)phenylamino)-5-carbamoylpyrimidin-2-ylamino)cyclohexylcarbamate 
• 1370261-98-5 4-(3-(2H-1,2,3-triazol-2-yl)phenylamino)-2-((1R, 2S)-2-aminocyclohexylamino)pyrimidine-5-carboxamide acetic acid salt 

Relevant articles and documents

Discovery of mercaptopropanamide-substituted aryl tetrazoles as new broad-spectrum metallo-β-lactamase inhibitors

β-Lactam antibiotic resistance mediated by metallo-β-lactamases (MBL) has threatened global public health. There are currently no available inhibitors of MBLs for clinical use. We previously reported the ruthenium-catalyzed meta-selective C-H nitration synthesis method, leading to some meta-mercaptopropanamide substituted aryl tetrazoles as new potent MBL inhibitors. Here, we described the structure-activity relationship of meta- and ortho-mercaptopropanamide substituted aryl tetrazoles with clinically relevant MBLs. The resulting most potent compound 13a showed IC50 values of 0.044 μM, 0.396 μM and 0.71 μM against VIM-2, NDM-1 and IMP-1 MBL, respectively. Crystallographic analysis revealed that 13a chelated to active site zinc ions via the thiol group and interacted with the catalytically important residues Asn233 and Tyr67, providing further structural information for the development of thiol based MBL inhibitors. This journal is

SELECTIVE KINASE INHIBITORS

Provided are pyrimidine compounds for inhibiting of Syk kinase, intermediates used in making such compounds, methods for their preparation, pharmaceutical compositions thereof, methods for inhibition Syk kinase activity, and methods for treating conditions mediated at least in part by Syk kinase activity.