6280-34-8

Basic information

• Product Name: 5-cyclohexyl-2H-tetrazole
• CAS NO: 6280-34-8
• Molecular Formula: C₇H₁₂N₄
• Molecular Weight: 152.197
• Mol File: 6280-34-8.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 311°C at 760 mmHg
• Flash Point: 145°C
• Density: 1.183g/cm³
• Vapor Pressure: 0.000578mmHg at 25°C
• Refractive Index: 1.547
• CAS DataBase Reference: 5-cyclohexyl-2H-tetrazole(CAS DataBase Reference)
• NIST Chemistry Reference: 5-cyclohexyl-2H-tetrazole(6280-34-8)
• EPA Substance Registry System: 5-cyclohexyl-2H-tetrazole(6280-34-8)

Safety Data

• Hazardous Substances Data: 6280-34-8(Hazardous Substances Data)

Upstream product

• 18039-42-4 5-Phenyl-1H-tetrazole 
• 766-05-2 cyclohexane carbonitrile 
• 4715-11-1 cyclohexanecarbaldoxime 

Downstream Products

• 142868-13-1 5-cyclohexyl-1-methyl-4-phenacyl-1H-tetrazolium iodide 
• 99993-12-1 [2-(5-cyclohexyl-tetrazol-2-yl)-ethyl]-dimethyl-amine 
• 143018-95-5 2-(5-cyclohexyltetrazol-2-yl)acetophenone 
• 143018-94-4 2-(5-cyclohexyltetrazol-1-yl)acetophenone 

Relevant articles and documents

TMSN3-Bu2Sn(OAc)2: A modified and mild reagent system for Wittenberger tetrazole-synthesis

Treatments of various nitriles with TMSN3 and Bu2Sn(OAc)2 at 30 °C in benzene for 60 h yielded the corresponding 5-substituted 1H-tetrazoles in good to excellent yields. This method is a mild and efficient alternative reagent system for Wittenberger tetrazole-synthesis that uses TMSN3 and Bu2SnO in toluene at high temperature (93–110 °C) for 24–72 h.

A Practical Synthesis of 5-Substituted 1 H -Tetrazoles from Aldoximes Employing the Azide Anion from Diphenyl Phosphorazidate

5-Substituted 1 H -tetrazoles were effectively synthesized from aldoximes and diphenyl phosphorazidate (DPPA) under reflux conditions in xylenes. Various aldoximes underwent the cycloaddition reaction to afford the corresponding 5-substituted 1 H -tetrazoles in short reaction times and in good yields. Chiral aldoximes derived from amino acids also gave aminotetrazoles with almost no racemization.

Preparation of 5-substituted 1H-tetrazoles catalyzed by scandium triflate in water

Several 5-substituted 1H-tetrazoles were prepared in water or isopropanol/water mixtures using microwave heating. Good yields were obtained for the [2 + 3] cycloaddition of sodium azide with aryl nitriles, aliphatic nitriles, and vinyl nitriles when catal