6280-80-4

Basic information

• Product Name: 2-Formylphenoxyacetic acid
• Synonyms: TIMTEC-BB SBB008189;O-FORMYLPHENOXYACETIC ACID;(2-formylphenoxy)-aceticaci;2-(2-Formylphenoxy)acetic acid;2-Carboxymethoxybenzaldehyde;Acetic acid, (2-formylphenoxy)-;Acetic acid, (o-formylphenoxy)-;AKOS B005809
• CAS NO: 6280-80-4
• Molecular Formula: C₉H₈O₄
• Molecular Weight: 180.16
• EINECS: 228-480-9
• Product Categories: Phenoxyacetic Acids and Alcohols (substituted);Aldehydes;C9;Carbonyl Compounds;Building Blocks;Carbonyl Compounds;Chemical Synthesis;Organic Building Blocks
• Mol File: 6280-80-4.mol
• Article Data: 16

Chemical Properties

• Melting Point: 129.5-132 °C(lit.)
• Boiling Point: 272.96°C (rough estimate)
• Flash Point: 151.1 °C
• Appearance: light brown crystalline powder
• Density: 1.2933 (rough estimate)
• Vapor Pressure: 6.14E-06mmHg at 25°C
• Refractive Index: 1.4500 (estimate)
• PKA: 3.04±0.10(Predicted)
• Sensitive: Air Sensitive
• BRN: 2096797
• CAS DataBase Reference: 2-Formylphenoxyacetic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Formylphenoxyacetic acid(6280-80-4)
• EPA Substance Registry System: 2-Formylphenoxyacetic acid(6280-80-4)

Safety Data

• Statements: 36/37/38
• Safety Statements: 24/25
• WGK Germany: 3
• TSCA: Yes
• Hazardous Substances Data: 6280-80-4(Hazardous Substances Data)

Usage

Chemical Properties

LIGHT BROWN CRYSTALLINE POWDER

Uses

2-Formylphenoxyacetic acid was used to synthesize azomethine derivatives. It was also used in the preparation of ligands L(1)H(2) and L(2)H(2).

InChI:InChI=1/C9H8O4/c10-5-7-3-1-2-4-8(7)13-6-9(11)12/h1-5H,6H2,(H,11,12)/p-1

Upstream product

• 41873-61-4 ethyl (2-formylphenoxy)acetate 
• 3926-62-3 sodium monochloroacetic acid 
• 90-02-8 salicylaldehyde 
• 89-95-2 2-methyl-benzyl alcohol 
• 79-11-8 chloroacetic acid 
• 96-32-2 bromoacetic acid methyl ester 
• 40359-34-0 methyl o-formylphenoxyacetate 
• 91143-61-2 3-oxo-2-phenoxy-propionic acid ethyl ester 

Downstream Products

• 271-89-6 1-benzofurane 
• 496-41-3 Benzofuran-2-carboxylic acid 
• 635-53-0 (2-carboxyphenoxy)acetic acid 
• 75270-15-4 (2-Formyl-phenoxy)-acetyl chloride 
• 227286-77-3 (E)-(2-hydroxyiminomethylphenoxy)acetic acid 
• 1646-27-1 methyl benzofuran-2-carboxylate 
• 141126-76-3 2-(3,5-Dimethoxycarbonyl-2,6-dimethyl-1,4-dihydro-pyridin-4-yl)phenoxyacetic Acid 
• 1267588-03-3 (2R,3S)-methyl 3-(2-oxo-2-phenylethyl)-2,3-dihydrobenzofuran-2-carboxylate 
• 1267588-05-5 (2R,3S)-N-isopropyl-3-(2-oxo-2-phenylethyl)-2,3-dihydrobenzofuran-2-carboxamide 
• 1267589-04-7 (E)-2-(2-(3-oxo-3-(4-methylphenyl)prop-1-en-1-yl)phenoxy)acetic acid 
• 93305-57-8 (E)-2-(2-(3-oxo-but-1-en-1-yl)phenoxy)acetic acid 
• 1267589-05-8 (E)-2-(2-(3-(4-chlorophenyl)-3-oxoprop-1-en-1-yl)phenoxy)acetic acid 
• 1352732-59-2 N-tert-butyl-7-(4-chlorobenzyl)-3-oxo-2,3,5,6,7,8-hexahydrobenzo[i][1,4,7]dioxazecine-8-carboxamide 
• 208711-58-4 benzofuran-3(2H)-one O-methyl oxime 

Relevant articles and documents

One-dimensional Europium-coordination polymer as luminescent sensor for highly selective and sensitive detection of 2,4,6-trinitrophenol

Three isostructural lanthanide coordination polymers (LnCPs), [Ln(L)6(DMF)]n {HL = 2-(2-formylphenoxy) acetic acid, Ln = Sm (1); Eu (2); Tb (3)} have been synthesized by solvothermal reaction and characterized. Single crystal analyse

Organocatalytic Synthesis of Fused Bicyclic 2,3-Dihydro-1,3,4-oxadiazoles through an Intramolecular Cascade Cyclization

Hydrazone-carboxylic acids undergo intramolecular cyclization in the presence of pivaloyl chloride, iPr2NEt, and catalytic DABCO to form a range of substituted fused tricyclic 2,3-dihydro-1,3,4-oxadiazoles in high yields.

A new fluorescent pH probe for imaging lysosomes in living cells

A new rhodamine B-based pH fluorescent probe has been synthesized and characterized. The probe responds to acidic pH with short response time, high selectivity and sensitivity, and exhibits a more than 20-fold increase in fluorescence intensity within the pH range of 7.5-4.1 with the pKa value of 5.72, which is valuable to study acidic organelles in living cells. Also, it has been successfully applied to HeLa cells, for its low cytotoxicity, brilliant photostability, good membrane permeability and no 'alkalizing effect' on lysosomes. The results demonstrate that this probe is a lysosome-specific probe, which can selectively stain lysosomes and monitor lysosomal pH changes in living cells.