62827-73-0Relevant articles and documents
Rhodium catalyzed carbon-hydrogen bond activation reaction for synthesizing isocoumarin derivative
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Paragraph 0074-0078; 0089-0091, (2021/04/10)
The invention belongs to the technical field of fine chemicals, and particularly relates to a preparation method of an isocoumarin derivative, and the isocoumarin derivative is a compound shown as a formula (I).
Method for synthesizing isocoumarin derivative under catalysis of silver and application of isocoumarin derivative
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Paragraph 0081-0086, (2021/05/12)
The invention belongs to the technical field of organic synthetic chemistry, and particularly relates to a method for synthesizing an isocoumarin derivative under catalysis of silver and application of the isocoumarin derivative. According to the method, 2-(phenylethynyl)benzaldehyde is taken as a model substrate, monovalent silver salt is taken as a catalyst, reaction is carried out at the temperature not lower than 30 DEG C, and the isocoumarin derivative is generated. In the field, 2-(phenylethynyl)benzaldehyde is used as a model substrate for the first time, and the isocoumarin derivative is prepared in one step under the catalytic action of the monovalent silver salt. The method is simple, convenient and efficient, the used raw materials are simple, easy to obtain and non-toxic, the steps are few, the conditions are mild, the cost is low, and the method is suitable for large-scale industrial production.
Palladium complexes with an annellated mesoionic carbene (MIC) ligand: Catalytic sequential Sonogashira coupling/cyclization reaction for one-pot synthesis of benzofuran, indole, isocoumarin and isoquinolone derivatives
Bera, Jitendra K.,Daw, Prosenjit,Reshi, Noor U Din,Tyagi, Akshi
supporting information, p. 15238 - 15248 (2020/11/18)
Two Pd(ii) complexes (1 and 2) featuring a fused π-conjugated imidazo[1,2-a][1,8]naphthyridine-based mesoionic carbene ligand have been synthesized and structurally characterized. Both complexes effectively catalyze the one-pot synthesis of benzofuran starting from phenylacetylene and 2-iodophenol under mild conditions. Complex 1 is found to be an excellent catalyst for the straightforward access to a library of benzofuran, indole, isocoumarin and isoquinolone derivatives by the reaction of terminal alkynes with 2-iodo derivates of phenol, N-methyl aniline, benzoic acid and N-methyl benzamide, respectively. The general utility of the catalytic method is demonstrated using a variety of diversely substituted terminal alkynes and the corresponding desired products are obtained in good to excellent yields. On the basis of control experiments, a two-cycle mechanism is proposed which involves the Sonogashira coupling of 2-iodo derivatives with alkynes and the subsequent cyclization of the corresponding 2-alkynyl compounds.