6284-79-3

Basic information

• Product Name: 3,4-Dichlorobenzophenone
• Synonyms: LABOTEST-BB LT00455525;(3,4-Dichlorophenyl)phenyl-methanone;3,4-DICHLOROBENZOPHENONE;3,4-Dichlorobenzophenone99%;3,4-Dichlorobenzophenone 99%;3,4-Dichlorobenzophenone,98%;3,4-DiChlororobenzo phenone;3,4-Dichlorophenyl phenyl ketone
• CAS NO: 6284-79-3
• Molecular Formula: C₁₃H₈Cl₂O
• Molecular Weight: 251.11
• EINECS: 228-509-5
• Product Categories: Aromatic Benzophenones & Derivatives (substituted);API intermediates
• Mol File: 6284-79-3.mol
• Article Data: 34

Chemical Properties

• Melting Point: 100-103 °C
• Boiling Point: 356.37°C (rough estimate)
• Flash Point: 159.3 °C
• Appearance: light brown to pink-grey crystalline powder
• Density: 1.2472 (rough estimate)
• Vapor Pressure: 7.08E-06mmHg at 25°C
• Refractive Index: 1.5555 (estimate)
• Storage Temp.: 2-8°C
• BRN: 2105069
• CAS DataBase Reference: 3,4-Dichlorobenzophenone(CAS DataBase Reference)
• NIST Chemistry Reference: 3,4-Dichlorobenzophenone(6284-79-3)
• EPA Substance Registry System: 3,4-Dichlorobenzophenone(6284-79-3)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 37/39-26-24/25
• Hazardous Substances Data: 6284-79-3(Hazardous Substances Data)

Usage

Chemical Properties

light brown to pink-grey crystalline powde

Uses

3,4-Dichlorobenzophenone has been used as a reactant for the preparation of chiral benzyl alcohols.

Synthesis

The synthesis of 3,4-Dichlorobenzophenone is as follows:In around-bottom flask, diarylmethanes (1.0 mmol), NBS (889.9 mg, 5.0 mmol) andwater (0 or 5.0 mmol) were dissolved in CHCl3?(4.0 mL). After refluxing for 3 h in the air, the reaction mixture was quenched withNa2S2O3·5H2O, cooled to roomtemperature, washed with 5mL CH2Cl2, dried with MgSO4,and filtered to get clear organic solution. The solvent was removed reduced pressure by a rotary evaporator, and the resulting residue was subjected to column chromatography on silica gel using co-solvent(ethyl acetate / petroleum ether, v/v) as eluent to give the corresponding diaryllketones.

InChI:InChI=1/C13H8Cl2O/c14-11-7-6-10(8-12(11)15)13(16)9-4-2-1-3-5-9/h1-8H

Upstream product

• 98-88-4 benzoyl chloride 
• 95-50-1 1,2-dichloro-benzene 
• 64471-83-6 3,4-dichlorobenzoyl formic acid 
• 98-80-6 phenylboronic acid 
• 51-44-5 3,4-dichlorbenzoic acid 
• 591-51-5 phenyllithium 
• 65-85-0 benzoic acid 
• 7446-70-0 aluminium trichloride 
• 168141-35-3 (3,4-Dichloro-phenyl)-phenyl-methanethione 
• 3024-72-4 3,4-dichlorobenzoyl chloride 
• 71-43-2 benzene 
• 98-07-7 Benzotrichlorid 
• 88875-60-9 α-(3,4-dichlorophenyl)phenylacetic acid 
• 201230-82-2 carbon monoxide 

Downstream Products

• 134917-58-1 3,4-dichloro-benzophenone-seqcis-oxime 
• 812684-92-7 2-(3,4-dichloro-phenyl)-2-phenyl-[1,3]dioxolane 
• 19264-66-5 9H-carbazole-3-yl(phenyl)methanone 
• 834895-58-8 1-(3-chloro-4-pyrrolidinophenyl)-1-phenylprop-2-yn-1-ol 
• 834895-44-2 3-(3-chloro-4-pyrrolidinophenyl)-3-phenyl-3H-naphtho[2,1-b]pyran 

Relevant articles and documents

Photo-induced oxidative cleavage of C-C double bonds of olefins in water

The carbonyl compounds, synthesized by the oxidative cleavage of their corresponding olefins, are of great significance in organic synthesis, especially aryl ketones. We have developed a gentle and effective protocol, using acid red 94 as the organic metal-free photocatalyst, O2 as the oxidant, and water as the solvent. Under visible light irradiation, aryl ketone derivatives were obtained in moderate to excellent yields, showing good economic and environmental advantages.

Aryl aldiketone and synthesis method thereof

The invention discloses an aryl aldehyde ketone and a synthesis method thereof, wherein an aryl aldehyde is synthesized from cheap olefin as a raw material. A commercially available inexpensive olefin is used as a raw material, ether is used as an additive, molecular oxygen serves as a sole oxidizing agent, water is used as a solvent, and the aldehyde and ketone are synthesized by column chromatography under a photocatalytic condition. The invention has the advantages of mild reaction conditions, green and environmental protection, simple experimental operation, good reaction selectivity, high product yield and the like.

Kinetically Controlled, Highly Chemoselective Acylation of Functionalized Grignard Reagents with Amides by N?C Cleavage

The direct transition-metal-free acylation of amides with functionalized Grignard reagents by highly chemoselective N?C cleavage under kinetic control has been accomplished. The method offers rapid and convergent access to functionalized biaryl ketones through transient tetrahedral intermediates. The direct access to functionalized Grignard reagents by in situ halogen–magnesium exchange promoted by the versatile turbo-Grignard reagent (iPrMgCl?LiCl) permits excellent substrate scope with respect to both the amide and Grignard coupling partners. These reactions enable facile, operationally simple and chemoselective access to tetrahedral intermediates from amides under significantly milder conditions than chelation-controlled intermediates. This novel direct two-component coupling sets the stage for using amides as acylating reagents in an alternative paradigm to the metal-chelated approach, acyl metals and Weinreb amides.