628731-58-8

Basic information

• Product Name: 8-FLUORO-3,4-DIHYDRONAPHTHALEN-1(2H)-ONE
• Synonyms: 8-FLUORO-3,4-DIHYDRONAPHTHALEN-1(2H)-ONE;8-Fluoro-1-tetralone;8-Fluoro-α-Tetralone;1(2H)-Naphthalenone,8-fluoro-3,4-dihydro-(9CI);8-Fluoro-3,4-dihydro-2H-naphthalen-1-one
• CAS NO: 628731-58-8
• Molecular Formula: C₁₀H₉FO
• Molecular Weight: 164.1762632
• Product Categories: HALIDE
• Mol File: 628731-58-8.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 267.8±29.0℃ (760 Torr)
• Flash Point: 101.9±14.5℃
• Appearance: /
• Density: 1.198±0.06 g/cm3 (20 ºC 760 Torr)
• Vapor Pressure: 0.00798mmHg at 25°C
• Refractive Index: 1.542
• CAS DataBase Reference: 8-FLUORO-3,4-DIHYDRONAPHTHALEN-1(2H)-ONE(CAS DataBase Reference)
• NIST Chemistry Reference: 8-FLUORO-3,4-DIHYDRONAPHTHALEN-1(2H)-ONE(628731-58-8)
• EPA Substance Registry System: 8-FLUORO-3,4-DIHYDRONAPHTHALEN-1(2H)-ONE(628731-58-8)

Safety Data

• Hazardous Substances Data: 628731-58-8(Hazardous Substances Data)

Usage

General Description

8-FLUORO-3,4-DIHYDRONAPHTHALEN-1(2H)-ONE is a chemical compound with the molecular formula C10H9FO. It is a fluorinated derivative of 1,2-dihydronaphthalene, which is a bicyclic aromatic hydrocarbon. 8-FLUORO-3,4-DIHYDRONAPHTHALEN-1(2H)-ONE is often used in organic synthesis and pharmaceutical research as a building block for the creation of various other compounds. Its structure and properties make it suitable for use as a starting material in the synthesis of pharmaceuticals and other complex organic molecules. The fluorine atom in its structure may impart specific chemical and physical properties that make it useful in the development of new drugs or in other industrial applications.

InChI:InChI=1/C10H9FO/c11-8-5-1-3-7-4-2-6-9(12)10(7)8/h1,3,5H,2,4,6H2

Upstream product

• 210346-49-9 8-aminotetralone 
• 540-80-7 tert.-butylnitrite 
• 2217-41-6 1-amino-5,6,7,8-tetrahydronaphthalene 
• 110139-15-6 N-(8-oxo-5,6,7,8-tetrahydronaphthalen-1-yl)acetamide 
• 6272-18-0 N-(5,6,7,8-tetrahydronaphthalen-1-yl)acetamide 

Downstream Products

• 700-45-8 5-fluoro-tetralin 

Relevant articles and documents

Regioselective Electrochemical Cyclobutanol Ring Expansion to 1-Tetralones

A mild electrochemical method for the regioselective preparation of 1-tetralones under environmentally friendly conditions from readily available cyclobutanols was developed. A series of aromatic- and heteroaromatic-fused 1-tetralones was accessed through ring expansion of the functionalized cyclobutanols via electrochemical generation of alkoxy radicals and intramolecular cyclization.

CARBAMATE DERIVATIVE COMPOUNDS, PROCESSES FOR PREPARING THEM AND THEIR USES

The present invention relates to a pharmaceutical composition for treating or preventing CNS disorders containing a carbamate derivative compound and/or pharmaceutically acceptable salt thereof as an active ingredient. Furthermore, the present invention relates to a method for treatment or prevention CNS disorders comprising administering a carbamate derivative compound in a pharmaceutically effective amount to a subject in need of treatment or prevention of CNS disorders.

4-(2-Methyl-5,6,7,8-tetrahydro-quinolin-7-ylmethyl)-1,3-dihydro-imidazole-2-thione as specific alpha2B agonist and methods of using the same

The compound of the formula wherein the * indicates an asymmetric carbon, is specific to alpha2B adrenergic receptors in preference over alpha2A and alpha2C adrenergic receptors, and as such has no or only minimal cardivascular and/or sedatory activity. The compound is useful as medicament in mammals, including humans, for treatment of diseases and or alleviations of conditions which are responsive to treatment by agonists of alpha2B adrenergic receptors.