6289-62-9Relevant articles and documents
Cyclopentanedi- and tricarboxylic acids as squalene synthase inhibitors: Syntheses and evaluation
Shen, Wang,Garvey, David S.,Cohen, Jerry,Stein, Herman,Rosenberg, Saul H.
, p. 891 - 896 (2007/10/03)
Based on earlier lead squalene synthase inhibitor A-87049 (3) and zaragozic acids, a series of cyclopentanedi- and tricarboxylic acids were synthesized and evaluated against the enzyme. Some exhibited good potency and SAR revealed the importance of conformation and substitution pattern of these synthetic inhibitors.
Enzyme mediated optical resolution of endo-norbornene lactone
Janssen,Klunder,Zwanenburg
, p. 7219 - 7222 (2007/10/02)
The enzymatic resolution of some norbornene esters, -carboxylic acids and -methanols was evaluated. Good results were obtained for the Porcine Pancreatic Lipase (PPL) catalyzed transesterification of norbornene methanols 12 and 13 in methyl acetate. A formal kinetic resolution of endo-norbornene lactone 7 could be achieved through the PPL-catalyzed transesterification of iodolactone 15 in methyl acetate. Both enantiomers of lactone 7 were obtained enantiomerically pure in good overall yields.