62928-11-4 Usage
Description
Dichlorodihydroxybis(isopropylamine)platinum, also known as iproplatin, is a platinum-based antineoplastic agent with a chemical formula of [Pt(NH(iPr)2)2(OH)2]Cl2. It is a coordination compound that contains two isopropylamine ligands, two hydroxyl groups, and two chloride ions. Iproplatin has a square planar geometry around the platinum atom, which is characteristic of many platinum-based drugs.
Uses
Used in Antineoplastic Applications:
Iproplatin is used as an antineoplastic agent for the treatment of various types of cancer. It works by inhibiting protein kinase C in rats, which is an essential enzyme in the cell signaling pathways that regulate cell growth and division. By inhibiting this enzyme, iproplatin can effectively suppress the growth and proliferation of cancer cells, making it a valuable tool in cancer therapy.
Used in Cancer Treatment:
Iproplatin is used in the treatment of various types of cancer, including testicular, ovarian, and lung cancer. It is particularly effective in treating testicular cancer, where it has shown significant success in combination with other chemotherapy drugs. The use of iproplatin in cancer treatment is based on its ability to form covalent bonds with DNA, leading to the formation of intrastrand and interstrand cross-links that disrupt the normal function of the DNA molecule and inhibit the replication and transcription processes in cancer cells.
Check Digit Verification of cas no
The CAS Registry Mumber 62928-11-4 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 6,2,9,2 and 8 respectively; the second part has 2 digits, 1 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 62928-11:
(7*6)+(6*2)+(5*9)+(4*2)+(3*8)+(2*1)+(1*1)=134
134 % 10 = 4
So 62928-11-4 is a valid CAS Registry Number.
InChI:InChI=1/2C3H8N.2ClH.2H2O.Pt/c2*1-3(2)4;;;;;/h2*3-4H,1-2H3;2*1H;2*1H2;/q2*-1;;;;;+4/p-2/r2C3H8N.Cl2Pt.2H2O/c2*1-3(2)4;1-3-2;;/h2*3-4H,1-2H3;;2*1H2/q2*-1;+2;;
62928-11-4Relevant articles and documents
Molecular interaction fields vs. quantum-mechanical-based descriptors in the modelling of lipophilicity of platinum(iv) complexes
Ermondi, Giuseppe,Caron, Giulia,Ravera, Mauro,Gabano, Elisabetta,Bianco, Sabrina,Platts, James A.,Osella, Domenico
supporting information, p. 3482 - 3489 (2013/03/28)
We report QSAR calculations using VolSurf descriptors to model the lipophilicity of 53 Pt(iv) complexes with a diverse range of axial and equatorial ligands. Lipophilicity is measured using an efficient HPLC method. Previous models based on a subset of these data are shown to be inadequate, due to incompatibility of whole molecule descriptors between carboxylato and hydroxido ligands. Instead, the interaction surfaces of complexes with various probes are used as independent descriptors. Partial least squares modelling using three latent variables results in an accurate (R2 = 0.92) and robust model (Q2 = 0.87) of lipophilicity, that moreover highlights the importance of size and hydrophobicity terms and the modest relevance of hydrogen bonding.
