62933-57-7

Basic information

• Product Name: 1',2'-O-diacetyl-L-biopterin
• Synonyms: 1',2'-O-diacetyl-L-biopterin
• CAS NO: 62933-57-7
• Molecular Weight: 321.293
• Mol File: 62933-57-7.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 478.7±55.0 °C(Predicted)
• Density: 1.58±0.1 g/cm3(Predicted)
• CAS DataBase Reference: 1',2'-O-diacetyl-L-biopterin(CAS DataBase Reference)
• NIST Chemistry Reference: 1',2'-O-diacetyl-L-biopterin(62933-57-7)
• EPA Substance Registry System: 1',2'-O-diacetyl-L-biopterin(62933-57-7)

Safety Data

• Hazardous Substances Data: 62933-57-7(Hazardous Substances Data)

Usage

Uses

Di-O-Acetylbiopterin, is an impurity of Sapropterin (T293175), a natural cofactor for phenylalanine hydroxylase, tyrosine hydroxylase, tryptophan hydroxylase, and nitric oxide synthase.An essential cofactor for the production of neurotransmitters such as catecholamines, serotonin, and nitric oxide. Increasing BH4 levels boosts sensivity to pain.

Upstream product

• 32363-64-7 2-N-Acetyl-1',2'-di-O-acetylbiopterin 
• 95895-36-6 5-deoxy-2,3,4-O-triacetyl-L-arabinose-phenylhydrazone 
• 1004-75-7 2,5,6-triamino-4-hydroxypyrimidine 
• 35011-47-3 2,4,5-triaminopyrimidin-6(1H)-one sulfate monohydrate 
• 13039-56-0 5-deoxy-L-arabinose 
• 59245-36-2 5-deoxy-L-arabinose phenylhydrazone 
• 1126386-90-0 C₁₁H₁₆O₇ 
• 123168-30-9 5-deoxy-L-ribose phenylhydrazone 
• 93978-94-0 5-deoxy-L-ribose 
• 4159-66-4 (R)-1-((4R,5S)-5-((S)-1-hydroxyethyl)-2,2-dimethyl-1,3-dioxolan-4-yl)ethane-1,2-diol 
• 35011-47-3 2,4,5-triamino-6-hydroxypyrimidine sulfate 
• 13039-80-0 5-deoxy-L-(+)-arabinose-diethylmercaptal 
• 5328-37-0 L-arabinose 
• 13039-79-7 5-tosyl-L-(+)-arabinose-diethylmercaptal 

Downstream Products

• 22150-76-1 L-erythro biopterin 
• 81827-31-8 2-N-acetyl-1',2'-di-O-acetyl-L-erythro-biopterin 
• 22150-76-1 biopterin 

Relevant articles and documents

Preparation method of sapropterin dihydrochloride

The invention relates to a preparation method of sapropterin dihydrochloride shown as formula (I) as shown in the specification. The preparation method comprises the steps of taking 5-deoxy arabinoseas a raw material, performing acetylation reaction in the presence of acetic anhydride to form an intermediate DL-1, allowing DL-1 to react with phenylhydrazine under the catalysis of acetic acid to form an intermediate DL-2, allowing DL-2 and pyrimidylamine sulfate to give a ring closing reaction under the catalysis of anhydrous lithium perchlorate to form an intermediate DL-3, directly oxidizingDL-3 through elemental iodine without purification to form an intermediate DL-4, hydrolyzing DL-4 through potassium hydroxide to form L-biopterin (DL-5), and reducing and salifying L-biopterin through a platinum catalyst to form sapropterin dihydrochloride. The preparation method is easy and simple to operate, high in yield, low in energy consumption and suitable for industrial production, the total yield of the preparation method is greater than 70%, and the purity of a final product reaches above 99.5%.

COMPOSITIONS AND METHODS FOR THE TREATMENT OF METABOLIC DISEASES

The invention relates to the compounds of formula I, formula II and formula III or its pharmaceutical acceptable salts, as well as polymorphs, solvates, enantiomers, stereoisomers and hydrates thereof. The pharmaceutical compositions comprising an effective amount of compounds of formula I, formula II or formula III; and methods for treating or preventing metabolic diseases may be formulated for oral, buccal, rectal, topical, transdermal, transmucosal, intravenous, parenteral administration, syrup, or injection. Such compositions may be used to treatment of phenylketonuria, cardiovascular disease, autism, ADHD, hypertension, endothelial dysfunction and chronic kidney disease.

Total synthesis of L-biopterin from L-tartaric acid via 5-deoxy-L-arabinose

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