630413-93-3Relevant articles and documents
New and practical method for synthesis of 1- and 1,3-substituted xanthines
Zavialov, Ilia A.,Dahanukar, Vilas H.,Nguyen, Hoa,Orr, Cecilia,Andrews, David R.
, p. 2237 - 2240 (2004)
A new and practical method for the synthesis of 1- and 1,3-substituted xanthines is reported. Direct base-promoted condensation of the imidazole precursor 1 with carbamates 2 gives 1-substituted 7-PMB xanthines 7 in good yields. Alkylation of these derivatives or their potassium salts proceeds under mild conditions to give functionalized 1,3-substituted 7-PMB xanthines 9 in good to excellent yields. The obtained 7-PMB-protected derivatives can be readily deprotected to give the parent 1- and 1,3-substituted xanthines.