63046-09-3 Usage
Description
6,4'-DIHYDROXYFLAVONE, also known as 6-hydroxy-2-(4-hydroxyphenyl)-4H-chromen-4-one (CAS# 63046-09-3), is a flavonoid compound with broad pharmacological activity. Flavonoids are a class of compounds known for their ability to bind to biomolecules such as enzymes, hormone carriers, and DNA, chelate transition metal ions, catalyze electron transport, and scavenge free radicals. 6,4'-DIHYDROXYFLAVONE, in particular, exhibits inhibitory activity against HIV-1 integrase and acts as a ligand to the estrogen receptor.
Uses
Used in Pharmaceutical Industry:
6,4'-DIHYDROXYFLAVONE is used as an inhibitor of HIV-1 integrase for its potential role in the development of antiretroviral therapies. Its ability to inhibit the integrase enzyme can help prevent the integration of the HIV virus into the host genome, thereby limiting viral replication and spread.
Used in Hormone Therapy:
6,4'-DIHDROXYFLAVONE is used as a ligand to the estrogen receptor, making it a potential candidate for hormone therapy applications. Its interaction with the estrogen receptor can help modulate hormonal balance and be utilized in the treatment of conditions related to estrogen levels.
Used in Antioxidant Formulations:
Due to its free radical scavenging properties, 6,4'-DIHYDROXYFLAVONE is used in antioxidant formulations to protect cells from oxidative damage. Its ability to neutralize free radicals can contribute to the prevention of various diseases and conditions associated with oxidative stress.
Used in Drug Delivery Systems:
6,4'-DIHYDROXYFLAVONE can be incorporated into drug delivery systems to enhance the bioavailability and therapeutic efficacy of other drugs. Its interaction with biomolecules and ability to chelate metal ions can improve the delivery and targeting of pharmaceutical agents.
Used in Nutraceutical Industry:
6,4'-DIHYDROXYFLAVONE can be used in the development of nutraceutical products due to its broad pharmacological activity and potential health benefits. Its presence in dietary supplements and functional foods can contribute to overall health and well-being.
Check Digit Verification of cas no
The CAS Registry Mumber 63046-09-3 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 6,3,0,4 and 6 respectively; the second part has 2 digits, 0 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 63046-09:
(7*6)+(6*3)+(5*0)+(4*4)+(3*6)+(2*0)+(1*9)=103
103 % 10 = 3
So 63046-09-3 is a valid CAS Registry Number.
InChI:InChI=1/C15H10O4/c16-10-3-1-9(2-4-10)15-8-13(18)12-7-11(17)5-6-14(12)19-15/h1-8,16-17H
63046-09-3Relevant articles and documents
COMPOUNDS FOR IMMUNOPOTENTIATION
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Page/Page column 119, (2010/02/15)
Methods of stimulating an immune response and treating patients responsive thereto with 3,4-di(1H-indol-3-yl)-1H-pyrrole-2,5-diones, staurosporine analogs, derivatized pyridazines, chromen-4-ones, indolinones, quinazolines, nucleoside analogs, and other small molecules are disclosed.
A Short and Facile Synthetic Route to Hydroxylated Flavones. New Syntheses of Apigenin, Tricin, and Luteolin
Nagarathnam, Dhanapalan,Cushman, Mark
, p. 4884 - 4887 (2007/10/02)
Reaction of lithium polyanions generated from o-hydroxyacetophenones 3a-f with O-silyloxylated benzoates 2a-d gave 1-aryl-3-(2-hydroxyphenyl)-1,3-propanediones 4a-n, which on treatment with acetic acid containing 0.5percent H2SO4 at 95 - 100 deg C afforded hydroxylated flavones 5-18 in high yields (76 - 92percent).
