63065-69-0Relevant articles and documents
Pyridinium-1-yl bisphosphonates are potent inhibitors of farnesyl diphosphate synthase and bone resorption
Sanders, John M.,Song, Yongcheng,Chan, Julian M. W.,Zhang, Yonghui,Jennings, Samuel,Kosztowski, Thomas,Odeh, Sarah,Flessner, Ryan,Schwerdtfeger, Christine,Kotsikorou, Evangelia,Meints, Gary A.,Gómez, Aurora Ortiz,González-Pacanowska, Dolores,Raker, Amy M.,Wang, Hong,Van Beek, Ermond R.,Papapoulos, Socrates E.,Morita, Craig T.,Oldfield, Eric
, p. 2957 - 2963 (2005)
We report the design, synthesis and testing of a series of novel bisphosphonates, pyridinium-1-yl-hydroxy-bisphosphonates, based on the results of comparative molecular similarity indices analysis and pharmacophore modeling studies of farnesyl diphosphate
Reactions of 1,4-Bis(trimethylsilyl)-1,4-dihydropyridines with Carbonyl Compounds: A New Method for Regioselective Synthesis of 3-Alkylpyridines
Tsuge, Otohiko,Kanemasa, Shuji,Naritomi, Toshio,Tanaka, Junji
, p. 1497 - 1504 (2007/10/02)
A new method for the alkyl group introduction at the 3-position of pyridines is described: Reductive disilylation of pyridine, its 2-methyl, 3-methyl, and 4-methyl derivatives affords the corresponding 1,4-disilyl-1,4-dihydropyridines.Tn the presence of a catalytic amount of tetrabutylammonium fluoride, these dihydropyridines smoothly react with a variety of aldehydes and ketones to give 3-alkylpyridines.
