63149-33-7

Basic information

• Product Name: 8-HYDROXYJULOLIDINE-9-ALDEHYDE
• Synonyms: 5h-benzo[ij]quinolizine-9-carboxaldehyde,2,3,6,7-tetrahydro-8-hydroxy-1;9-FORMYL-8-HYDROXYJULOLIDINE;9-FORMYL-2,3,6,7-TETRAHYDRO-1H,5H-BENZO[IJ]QUINOLIZIN-8-OL;8-HYDROXYJULOLIDINE-9-CARBOXALDEHYDE;8-HYDROXYJULOLIDINE-9-ALDEHYDE;8-HYDROXY-2,3,6,7-TETRAHYDRO-1H,5H-PYRIDO[3,2,1-IJ]QUINOLINE-9-CARBALDEHYDE;8-HYDROXY-2,3,6,7-TETRAHYDRO-1H,5H-BENZO[I,J]QUINOLIZINE-9-CARBOXALDEHYDE;AKOS NCG-0055
• CAS NO: 63149-33-7
• Molecular Formula: C₁₃H₁₅NO₂
• Molecular Weight: 217.26
• EINECS: 263-966-4
• Product Categories: A to Z;Aldehydes;Building Blocks;C13-C60;Carbonyl Compounds;Chemical Synthesis;Dyes;Hematology and Histology;Organic Building Blocks;Stains &Stains and Dyes;T-U-V
• Mol File: 63149-33-7.mol
• Article Data: 25

Chemical Properties

• Melting Point: 69-73°C
• Boiling Point: 417.3 °C at 760 mmHg
• Flash Point: 206.2 °C
• Appearance: /
• Density: 1.3 g/cm³
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• PKA: 9.47±0.20(Predicted)
• CAS DataBase Reference: 8-HYDROXYJULOLIDINE-9-ALDEHYDE(CAS DataBase Reference)
• NIST Chemistry Reference: 8-HYDROXYJULOLIDINE-9-ALDEHYDE(63149-33-7)
• EPA Substance Registry System: 8-HYDROXYJULOLIDINE-9-ALDEHYDE(63149-33-7)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• WGK Germany: 3
• TSCA: Yes
• HazardClass: IRRITANT
• Hazardous Substances Data: 63149-33-7(Hazardous Substances Data)

Usage

Uses

8-Hydroxyjulolidine-9-carboxaldehyde is a reactant in the development of iminocoumarin-based zinc sensor suitable for ratiometric fluorescence imaging of neuronal zinc.

InChI:InChI=1/C13H15NO2/c15-8-10-7-9-3-1-5-14-6-2-4-11(12(9)14)13(10)16/h7-8,16H,1-6H2

Upstream product

• 41175-50-2 8-hydroxyjulolidine 
• 68-12-2 N,N-dimethyl-formamide 
• 591-27-5 m-Hydroxyaniline 
• 109-70-6 1.3-chlorobromopropane 
• 536-90-3 m-Anisidine 
• 63468-83-7 8-methoxy-1,2,3,5,6,7-hexahydropyrido[3,2,1-ij]quinoline 

Downstream Products

• 83179-50-4 9.9'-carbonylbis(1,2,4,5-tetrahydro-3H,6H,10H<1>benzopyrano<9,9a,1-gh>quinolazine-10-one) 
• 55804-66-5 ethyl 11-oxo-2,3,6,7-tetrahydro-1H,5H,11H-pyrano[2,3-f ]-pyrido[3,2,1-ij]quinoline-10-carboxylate 
• 1477501-36-2 C₁₉H₂₀N₂O₂ 
• 55804-67-6 10-acetyl-2,3,6,7-tetrahydro-1H-pyrano[2,3-f]pyrido[3,2,1-ij]quinoline-11(5H)-one 
• 55804-68-7 coumarin 337 

Relevant articles and documents

A novel colorimetric chemosensor for Cu2+ with high selectivity and sensitivity based on rhodamine B

9-formyl-8-hydroxy-2,3,6,7-tetrahydro-1H, 5H-benzo[ij]-quinolizine rhodamine B hydrazone (FHQRH), a novel colorimetric chemosensor for Cu2+, was synthesized by a three-step synthetic route. It was found that FHQRH showed a high selectivity for Cu2+ ions and excellent anti-interference capability toward other metal ions. The FHQRH solution exhibited a visual color change after the addition of Cu2+, owing to the open spirocyclic structure via coordination with Cu2+. The complexation coefficient of FHQRH toward Cu2+ was measured to be 1:1. Furthermore, this Cu2+ chemosensor has a remarkable low detection limit of 0.45 μM, which is 2 % of the toxic level (20 μM) in drinking water as defined by the US Environment Protection Agency (EPA).

Three lysocolorimetric/lysofluorescent probes with mitochondria/lysosome dual targeting positioning

The invention discloses a preparation method of three lysocolorimetric/lysofluorescent probes with mitochondria/lysosome dual targeting positioning and application thereof in biological imaging, which belong to the technical field of chemical analysis and detection. The structure and the detection mechanism of the lysocolorimetric/lysofluorescent probes are as follows: the probes prepared have stronger solvent-induced discoloration characteristics, and the fluorescent quantum yield is relatively high. Cell experiments show that the prepared probe has a good mitochondria/lysosome positioning effect.

A novel fluorescent probe with dual-sites for simultaneously monitoring metabolisms of cysteine in living cells and zebrafishes

Understanding cellular metabolism holds immense potential for developing new drugs that regulate metabolic pathways. Two gas signal molecules, SO2 and H2S, are the main metabolites from cysteine (Cys) via oxidation and desulfurization pathways, respectively. However, a few fluorescent probes for real-time monitor of the metabolic pathways of cysteine have been reported. To understand metabolic alterations of cysteine, we have rationally designed and prepared a dual-signal fluorescent probe HN, which could differentiate SO2 and H2S through two different fluorescence channels simultaneously, along with similar reaction kinetics and both “off-on” fluorescence responses. Probe HN exhibits the potential to monitor the metabolism pathways of cysteine, and the distinguishment of cancer cells from normal cells could be realized. This methodology will promote further understanding of the physiological and pathological roles of cysteine.