63158-59-8Relevant articles and documents
SUBSTITUTED INDOLE MCL-1 INHIBITORS
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Paragraph 00406, (2015/12/08)
The present invention provides for compounds that inhibit the activity of an anti-apoptotic Bcl-2 family member Myeloid cell leukemia-1 (Mcl-1) protein. The present invention also provides for pharmaceutical compositions as well as methods for using compounds for treatment of diseases and conditions (e.g., cancer) characterized by the over-expression or dysregulation of Mcl-1 protein.
3-(2-Carboxyindol-3-yl)propionic Acid-Based Antagonists of the N-Methyl-D-aspartic Acid Receptor Associated Glycine Binding Site
Salituro, Francesco G.,Harrison, Boyd L.,Baron, Bruce M.,Nyce, Philip L.,Stewart, Kenneth T.,et al.
, p. 1791 - 1799 (2007/10/02)
A series of substituted 3-(2-carboxyindol-3-yl)propionic acids was synthesized and tested as antagonists for the strychnine-insensitive glycine binding site of the NMDA receptor.Chlorine, and other small electron-withdrawing substituents in the 4- and 6-p