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63189-98-0

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63189-98-0 Usage

Synthesis Reference(s)

Journal of Medicinal Chemistry, 34, p. 1110, 1991 DOI: 10.1021/jm00107a035

Check Digit Verification of cas no

The CAS Registry Mumber 63189-98-0 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 6,3,1,8 and 9 respectively; the second part has 2 digits, 9 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 63189-98:
(7*6)+(6*3)+(5*1)+(4*8)+(3*9)+(2*9)+(1*8)=150
150 % 10 = 0
So 63189-98-0 is a valid CAS Registry Number.

63189-98-0SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 13, 2017

Revision Date: Aug 13, 2017

1.Identification

1.1 GHS Product identifier

Product name (3,4-diaminophenyl)methanol

1.2 Other means of identification

Product number -
Other names (3,4-diamino-phenyl)-methanol

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:63189-98-0 SDS

63189-98-0Relevant articles and documents

Synthesis and Characterization of an Epidermal Growth Factor Receptor-Selective RuII Polypyridyl–Nanobody Conjugate as a Photosensitizer for Photodynamic Therapy

Karges, Johannes,Jakubaszek, Marta,Mari, Cristina,Zarschler, Kristof,Goud, Bruno,Stephan, Holger,Gasser, Gilles

, p. 531 - 542 (2019/11/13)

There is a current surge of interest in the development of novel photosensitizers (PSs) for photodynamic therapy (PDT), as those currently approved are not completely ideal. Among the tested compounds, we have previously investigated the use of RuII

A highly selective ratiometric fluorescent probe for 1,4-dithiothreitol (DTT) detection

Zhu, Baocun,Zhang, Xiaoling,Jia, Hongying,Li, Yamin,Liu, Haipeng,Tan, Weihong

scheme or table, p. 1650 - 1654 (2010/07/04)

A highly selective ratiometric fluorescent probe, which contains an aminonaphthalimide fluorophore and a self-immolative spacer for 1,4-dithiothreitol (DTT) detection was designed and synthesized. The probe displays a 66 nm red-shift of fluorescence emiss

Structure-activity relationship of omeprazole and analogues as Helicobacter pylori urease inhibitors

Kuhler,Fryklund,Bergman,Weilitz,Lee,Larsson

, p. 4906 - 4916 (2007/10/03)

Helicobacter pylori urease belongs to a family of highly conserved urea- hydrolyzing enzymes. A common feature of these enzymes is the presence of two Lewis acid nickel ions and a reactive cysteine residue in the active site. The H+/K+-ATPase inhibitor omeprazole is a prodrug of a sulfenamide which covalently modifies cysteine residues on the luminal side of the H+/K+- ATPase of gastric parietal cells. Omeprazole and eight analogues were selected based on their chemical, electronic, and kinetic properties, and each was incubated with viable H. pylori in phosphate-buffered saline at pH 7.4 for 30 min, after which 100 mM urea was added and the amount of ammonia formed analyzed after a further 10 min. Inhibition between 0% and 100% at a 0.1 mM concentration was observed for the different analogues and could be expressed as a function of the pK(a)-value of the pyridine, the pK(a)-value of the benzimidazole, the overall lipophilicity, and, most importantly, the rate of sulfenamide formation, in a quantitative structure-activity relationship. The inhibition was potentiated by a lower pH (favoring the formation of the sulfenamide) but abolished in the presence of β- mercaptoethanol (a scavenger of the sulfenamide). Structural analogues incapable of yielding the sulfenamide did not inhibit ammonia production. Treatment of Helicobacter felis-infected mice with 230 μmol/kg flurofamide b.i.d. for 4 weeks, known to potently inhibit urease activity in vivo, as a means of eradicating the infection, was tested and compared with the effect of 125 μmol/kg omeprazole b.i.d. for 4 weeks. Neither treatment proved efficacious.

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