6319-96-6

Basic information

• Product Name: N-CHLOROACETYLGLYCINE
• Synonyms: n-chloroacetylglycinecrystalline;N-ALPHA-CHLORACETYL-GLYCINE;N-CHLOROACETYL GLY;N-CHLOROACETYLGLYCINE;(2-CHLORO-ACETYLAMINO)-ACETIC ACID;AKOS USSH-4110465;CLAC-GLY-OH;CHLORACETYL GLYCINE
• CAS NO: 6319-96-6
• Molecular Formula: C₄H₆ClNO₃
• Molecular Weight: 151.55
• Product Categories: API intermediates;A - H;Amino Acids;Modified Amino Acids
• Mol File: 6319-96-6.mol
• Article Data: 11

Chemical Properties

• Melting Point: 96-98°C
• Boiling Point: 431.6 °C at 760 mmHg
• Flash Point: 214.8 °C
• Appearance: /
• Density: 1.422 g/cm³
• Vapor Pressure: 1.17E-08mmHg at 25°C
• Refractive Index: 1.486
• Storage Temp.: −20°C
• Water Solubility: almost transparency in Water
• BRN: 1765217
• CAS DataBase Reference: N-CHLOROACETYLGLYCINE(CAS DataBase Reference)
• NIST Chemistry Reference: N-CHLOROACETYLGLYCINE(6319-96-6)
• EPA Substance Registry System: N-CHLOROACETYLGLYCINE(6319-96-6)

Safety Data

• Statements: 36/37/38
• Safety Statements: 26-36
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 6319-96-6(Hazardous Substances Data)

Usage

Chemical Properties

White powder

InChI:InChI=1/C4H6ClNO3/c5-1-3(7)6-2-4(8)9/h1-2H2,(H,6,7)(H,8,9)

Upstream product

• 76969-81-8 (2-chloroacetylamino)acetic acid methyl ester 
• 556-50-3 glycylglycine 
• 79-04-9 chloroacetyl chloride 
• 56-40-6 glycine 

Downstream Products

• 33932-97-7 [2-(Ethoxy-methyl-phosphinothioylsulfanyl)-acetylamino]-acetic acid 
• 117900-91-1 (-)-N-(Chloroacetyl)glycin-<(1R,3R,4S)-menthyl>ester 
• 1474030-25-5 C₁₀H₁₁NO₃Se 
• 1002354-56-4 O-hydroxysuccinimidyl N-chloroacetylglycinate 
• 682334-38-9 [(3-amino-4-phenyl-6-thiophen-2-yl-thieno[2,3-b]pyridine-2-carbonyl)-amino]-acetic acid 
• 682334-33-4 [2-(3-cyano-4-phenyl-6-thiophen-2-yl-pyridin-2-ylsulfanyl)-acetylamino]-acetic acid 
• 180776-67-4 (S)-2-[2-(2-Chloro-acetylamino)-acetylamino]-3-phenyl-propionic acid methyl ester 
• 128781-39-5 N-<<(4-tert-butylphenyl)thio>acetyl>glycine 
• 99841-56-2 Bz-Gly-Gly 
• 38082-72-3 sarcosine-glycine 
• 556-50-3 glycylglycine 

Relevant articles and documents

PRODRUGS OF ABIRATERONE

The present invention relates to compounds of formula (I), or their isotopic forms, stereoisomers, tautomers, or pharmaceutically acceptable salt(s) thereof as prodrugs of abiraterone. The present invention also describes method of making such compounds, pharmaceutical compositions comprising such compounds and the use of the compounds of formula (I).

One-pot synthesis of phenylseleno N-acetyl α-amino acids: Supra-molecular self-assembling in organoselenium compounds

A convenient one-pot synthesis of phenylseleno N-acetyl α-amino acids, PhSeCH2C(O)NHC(R)COOH (R = H (1), Me (2), PhCH2 (3), 4-HOC6H4CH2 (4) and CH2OH (5)) is reported. These compounds have been characterized by microanalyses, UV-Vis, IR and NMR (1H, 13C, 77Se) spectroscopy. The molecular structures of [PhSeCH2CONHCH2COOH] (1), [PhSeCH2CONHCH(CH2C6H4OH-4)COOH] (4) and [PhSeCH2CONHCH(CH2OH)COOH] (5) have been established by X-ray diffraction analyses. These compounds are associated in the solid state through hydrogen bonding to give supra-molecular self-assembled structures. Free radical scavenging activity of these compounds has also been evaluated by DPPH assay.

7-Oxabicycloheptyl Carboxylic Acids as Thromboxane A2 Antagonists: Aza ω-Chain Analogues

A novel bicyclic prostaglandin analogue, >-7-acetyl>amino>methyl>-7-oxabicyclohept-2-yl>-5-heptenoic acid ((-)-7) was found to be a potent and selective thromboxane A2 (TxA2) receptor antagonist.Unlike the related series of ω-chain allylic alcohols, amide 7 and its congeners were uniformly free of direct contractile activity in vitro (bovine coronary) and in vivo (anesthetized guinea pig).Amide 7 was effective in the inhibition of (a) arachidonic acid induced platelet aggregation of human platelet-richplasma (I50 = 0.18 +/- 0.006 μM), (b) 11,9-epoxymethano-PGH2 induced platelet aggregation of human platelet-rich plasma (I50 = 0.24 μM), (c) 11,9-epoxymethano-PGH2 induced contraction of guinea pig trachea (Kb = 3.0 +/- 0.3 nM) or rat aorta (Kb = 8.8 +/- 1.1 nM), and (d) arachidonic acid induced bronchoconstriction in the anesthetized guinea pig (0.1-1.0 mg/kg iv).Amide 7 inhibited the binding of ->-7-hydrazino>methyl>-7-oxabicyclohept-2-yl>-5-heptenoic acid to human platelet membranes in a specific and saturable manner with a Kd = 49.6 +/- 1.4 nM.