63242-13-7Relevant articles and documents
Catalytic Decarboxylative Cross-Coupling of Aryl Chlorides and Benzoates without Activating ortho Substituents
Tang, Jie,Biafora, Agostino,Goossen, Lukas J.
, p. 13130 - 13133 (2015)
The restriction of decarboxylative cross-coupling reactions to ortho-substituted or heterocyclic carboxylate substrates was overcome by holistic optimization of a bimetallic Cu/Pd catalyst system. The combination of a CuI/Me4phen decarboxylation catalyst and a [(MeCN)4Pd](OTf)2/XPhos cross-coupling catalyst enables the synthesis of biaryls from inexpensive aryl chlorides and potassium benzoates regardless of their substitution pattern. Lifting the restriction: A combination of a CuI/Me4phen decarboxylation catalyst and a [(MeCN)4Pd](OTf)2/XPhos cross-coupling catalyst enables the synthesis of biaryls from inexpensive aryl chlorides and potassium benzoates regardless of their substitution pattern (see scheme; FG=functional group). This approach lifts the restriction of decarboxylative cross-coupling reactions to ortho-substituted or heterocyclic carboxylate substrates.
Remarkably effective phosphanes simply with a PPh2 moiety: Application to Pd-Catalysed cross-coupling reactions for tetra-ortho-substituted biaryl syntheses
So, Chau Ming,Chow, Wing Kin,Choy, Pui Ying,Lau, Chak Po,Kwong, Fuk Yee
supporting information; experimental part, p. 7996 - 8001 (2010/09/05)
Chemical equation presented Expanding the horizons of ArPPh2: New applications of triarylphosphane ligands are presented. The Pd-L1 and Pd-L2 complexes offer exceptionally high activity in Suzuki-Miyaura cross-couplings of aryl chlorides. The extremely congested synthesis of tetraortho-substituted biaryl compounds is achieved for the first time by simply using triarylphosphane ligands.
