63277-54-3

Basic information

• Product Name: Ethyl 1,3,4,5-tetrahydro-2H-pyrido[4,3,b]indole-2-carboxylate
• Synonyms: 1,3,4,5-TETRAHYDRO,ETHYL ESTER,2H-PYRIDO[4,3-B]INDOLE-2-CARBOXYLIC ACID;2H-PYRIDO[4,3,B]INDOLE-2-CARBOXYLIC ACID ,1,3,4,5-TETRAHYDRO,ETHYL ESTER;ethyl 1,3,4,5-tetrahydro-2h-pyrido[4,3,b]indole-2-carboxylate;1,3,4,5-TETRAHYDRO-2H-PYRIDO[4,3,B]INDOLE-2-CARBOXYLIC ACID ETHYL ESTER
• CAS NO: 63277-54-3
• Molecular Formula: C₁₄H₁₆N₂O₂
• Molecular Weight: 244.29
• Mol File: 63277-54-3.mol
• Article Data: 14

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Ethyl 1,3,4,5-tetrahydro-2H-pyrido[4,3,b]indole-2-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: Ethyl 1,3,4,5-tetrahydro-2H-pyrido[4,3,b]indole-2-carboxylate(63277-54-3)
• EPA Substance Registry System: Ethyl 1,3,4,5-tetrahydro-2H-pyrido[4,3,b]indole-2-carboxylate(63277-54-3)

Safety Data

• Hazardous Substances Data: 63277-54-3(Hazardous Substances Data)

Usage

General Description

Ethyl 1,3,4,5-tetrahydro-2H-pyrido[4,3,b]indole-2-carboxylate is a chemical compound with a complex structure that contains both a pyridoindole and an ester functional group. It is used in the pharmaceutical industry for the synthesis of various drugs and pharmacological research. Ethyl 1,3,4,5-tetrahydro-2H-pyrido[4,3,b]indole-2-carboxylate has a wide range of potential biological activities, including antifungal, anti-inflammatory, and analgesic properties. Its unique structure and diverse pharmacological activities make it a valuable target for drug development and research in the fields of medicinal chemistry and pharmacology.

Upstream product

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Downstream Products

• 1189545-83-2 5-benzenesulfonyl-1,3,4,5-tetrahydro-pyrido[4,3-b]indole-2-carboxylic acid ethyl ester 
• 199725-38-7 (+/-)-ethyl cis-1,3,4,4a,5,9b-hexahydro-2H-pyrido[4,3-b]indole-2-carboxylate 
• 82884-22-8 5-Phenyl-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole 
• 56756-99-1 2-Methyl-5-phenyl-2,3,4,5-tetrahydro-2-methyl-1H-pyrido[4,3-b]indol 
• 618910-05-7 5-benzyl-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole 
• 618910-03-5 5-ethyl-1H,2H,3H,4H,5H-pyrido[4,3-b]indole 
• 688030-07-1 5-benzyl-1,3,4,5-tetrahydro-pyrido[4,3-b]indole-2-carboxylic acid ethyl ester 

Relevant articles and documents

Enantioselective synthesis of cis-hexahydro-γ-carboline derivatives via Ir-catalyzed asymmetric hydrogenation

A novel synthetic route was developed for the construction of a chiral cis-hexahydro-γ-carboline derivative through Ir/ZhaoPhos-catalyzed asymmetric hydrogenation of corresponding tetrahydro-γ-carboline with high yields (up to 99% yield), excellent diastereoselectivities (up to >99 : 1 dr) and enantioselectivities (up to 99% ee), and high substrate-to-catalyst ratios (up to 5000).

Modified carbazoles destabilize microtubules and kill glioblastoma multiform cells

Small molecules that target microtubules (MTs) represent promising therapeutics to treat certain types of cancer, including glioblastoma multiform (GBM). We synthesized modified carbazoles and evaluated their antitumor activity in GBM cells in culture. Modified carbazoles with an ethyl moiety linked to the nitrogen of the carbazole and a carbonyl moiety linked to distinct biaromatic rings exhibited remarkably different killing activities in human GBM cell lines and patient-derived GBM cells, with IC50 values from 67 to >10,000 nM. Measures of the activity of modified carbazoles with tubulin and microtubules coupled to molecular docking studies show that these compounds bind to the colchicine site of tubulin in a unique low interaction space that inhibits tubulin assembly. The modified carbazoles reported here represent novel chemical tools to better understand how small molecules disrupt MT functions and kill devastating cancers such as GBM.

NEW Na-SUBSTITUTED CARBOLINE COMPOUNDS USABLE FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES

The present invention relates to a compound according to Formula (III) or a pharmaceutically acceptable salt, solvate, clathrate, hydrate or polymorph thereof and its use.