63352-56-7

Basic information

• Product Name: 1-Benzyl-2,3-piperazinedione
• Synonyms: 1-Benzyl-2,3-piperazinedione;1-Benzyl-2,3-dioxopiperazine;1-Benzyl-piperazine-2,3-dione
• CAS NO: 63352-56-7
• Molecular Formula: C₁₁H₁₂N₂O₂
• Molecular Weight: 204.23
• Product Categories: pharmacetical
• Mol File: 63352-56-7.mol
• Article Data: 2

Chemical Properties

• Appearance: /
• Density: 1.238g/cm³
• Refractive Index: 1.579
• Storage Temp.: Refrigerator
• Solubility: Chloroform (Slightly), Methanol (Slightly, Heated)
• CAS DataBase Reference: 1-Benzyl-2,3-piperazinedione(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Benzyl-2,3-piperazinedione(63352-56-7)
• EPA Substance Registry System: 1-Benzyl-2,3-piperazinedione(63352-56-7)

Safety Data

• Hazardous Substances Data: 63352-56-7(Hazardous Substances Data)

Usage

Uses

1-Benzyl-2,3-dioxopiperazine is an intermediate used in the new process for the synthesis of Piperacillin sodium.

InChI:InChI=1/C11H12N2O2/c14-10-11(15)13(7-6-12-10)8-9-4-2-1-3-5-9/h1-5H,6-8H2,(H,12,14)

Upstream product

• 77917-07-8 N,N'-dibenzyl-2,3-diketopiperazine 
• 4152-09-4 N-benzylethylenediamine 
• 553-90-2 Dimethyl oxalate 
• 2759-28-6 1-phenylmethylpiperazine 

Downstream Products

• 1375312-53-0 C₁₅H₁₈N₂O₄ 
• 1375313-00-0 C₁₆H₂₀N₂O₄ 
• 1375312-83-6 C₁₅H₁₈N₂O₄ 
• 1375312-45-0 C₁₄H₁₆N₂O₄ 
• 321860-08-6 1-benzyl-4-isopropyl-piperazine-2,3-dione 
• 1375301-11-3 1-benzyl-4-isobutylpiperazine-2,3-dione 
• 1375301-10-2 C₁₄H₁₈N₂O₂ 
• 1375301-09-9 C₁₅H₂₀N₂O₂ 
• 321860-07-5 1-benzyl-4-cyclopropyl-piperazine-2,3-dione 
• 77917-07-8 N,N'-dibenzyl-2,3-diketopiperazine 
• 1375301-15-7 C₁₅H₁₈N₂O₂ 
• 1375301-34-0 C₁₆H₂₀N₂O₂ 

Relevant articles and documents

Piperazines as model substrate for oxidations

Piperazine derivatives when being oxidized by mercury-EDTA behave unusually. Due to the reactive cyclic enediamine intermediates as aza-analogous reductones and to the carbonyl compounds resulting from dehydrogenation in the side chain, there exists a high tendency of polymerization. 1-Benzylpiperazines 5a-d generate the piperazine-2,3-diones 8a-d in medium yields. From 1-benzhydrylpiperazine 11 results a mixture of piperazine-2,3-dione 12 and piperazine-3-on 13. The 1,4-bis-substituted piperazines react more differently because of the symmetry and the preferred direction of the dehydrogenation into the cycle. Thus, from 15 and 19 the diones 16 and 20, respectively, were available in very good yields. A mechanism for the reactions is proposed.