634182-04-0Relevant articles and documents
Efficient kinetic resolution in the asymmetric transfer hydrogenation of 3-aryl-indanones: Applications to a short synthesis of (+)-indatraline and a formal synthesis of (R)-tolterodine
Lee, Hyeon-Kyu,Park, Songsoon
, p. 23161 - 23183 (2021/07/24)
Efficient kinetic resolution (KR) occurs in asymmetric transfer hydrogenation (ATH) reactions of racemic 3-aryl-1-indanones using commercial (R,R)- or (S,S)-Ts-DENEB as a catalyst, a 1?:?5 mixture of HCO2H and Et3N as a hydrogen source and MeOH as solvent
Asymmetric Hydroarylation of Enones via Nickel-Catalyzed 5- Endo-Trig Cyclization
Qin, Xurong,Yao Lee, Marcus Wen,Zhou, Jianrong Steve
supporting information, p. 5990 - 5994 (2019/08/20)
A nickel-catalyzed reductive cyclization of enones affords a wide array of indanones in high enantiomeric induction. The reaction is featured with an unprecedented broad scope of substrates. The versatility of the new method is demonstrated in several short stereoselective syntheses of medically valuable (R)-tolterodine, parent and deuterated (+)-indatraline, and an antitumor natural product, (+)-multisianthol. In comparison, these compounds cannot be prepared satisfactorily via analogous processes catalyzed by palladium.
Asymmetric Induction in Hydroacylation by Cooperative Iminium Ion-Transition-Metal Catalysis
Rastelli, Ettore J.,Truong, Ngoc T.,Coltart, Don M.
, p. 5588 - 5591 (2016/11/17)
A new strategy for the rhodium-catalyzed enantioselective hydroacylation is described. This has been achieved through the merger of iminium ion catalysis and transition-metal catalysis such that asymmetric induction derives from a readily accessible, inexpensive chiral nonracemic secondary amine catalyst rather than a chiral nonracemic phosphine as is typical of conventional asymmetric hydroacylation methods.
