634193-54-7 Usage
Description
L-902,688 is a highly potent agonist of the human Prostaglandin E2 (PGE2) receptor, specifically targeting the EP4 subtype. It is characterized by a Ki value of 0.38 nM and an EC50 value of 0.6 nM, showcasing its high affinity and potency. L-902,688 is also highly selective for the EP4 receptor, being more than 4,000-fold selective over other EP and prostanoid receptors. L-902,688 has been observed to induce thermal hyperalgesia in guinea pigs and increase vasodilation in human pulmonary veins.
Uses
Used in Pharmaceutical Research:
L-902,688 is used as a research tool for studying the role of the EP4 receptor in various physiological and pathological processes. Its high potency and selectivity make it a valuable compound for investigating the underlying mechanisms of EP4 receptor activation and its implications in bone formation, resorption, cancer, and atherosclerosis.
Used in Pain Management Research:
As L-902,688 has been shown to induce thermal hyperalgesia in guinea pigs, it can be used as a research compound to better understand the mechanisms of pain sensation and the potential development of novel pain management therapies.
Used in Cardiovascular Research:
Due to its ability to increase vasodilation in human pulmonary veins, L-902,688 can be utilized in cardiovascular research to explore the effects of EP4 receptor activation on vascular function and the potential development of treatments for conditions related to vascular health.
Used in Cancer Research:
L-902,688's role in cancer-related processes can be further investigated, particularly in understanding the EP4 receptor's involvement in tumor growth and progression. This may lead to the development of targeted therapies that leverage the EP4 receptor as a means to combat cancer.
Used in Drug Development:
The high potency and selectivity of L-902,688 make it a promising candidate for the development of new drugs targeting the EP4 receptor. These drugs could potentially be used in the treatment of conditions such as bone disorders, atherosclerosis, and cancer, where EP4 receptor modulation may provide therapeutic benefits.
Check Digit Verification of cas no
The CAS Registry Mumber 634193-54-7 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 6,3,4,1,9 and 3 respectively; the second part has 2 digits, 5 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 634193-54:
(8*6)+(7*3)+(6*4)+(5*1)+(4*9)+(3*3)+(2*5)+(1*4)=157
157 % 10 = 7
So 634193-54-7 is a valid CAS Registry Number.
