634600-99-0

Basic information

• Product Name: Benzenepropanoic acid, a-methyl-, 4-[[(1,1-dimethylethoxy)carbonyl]amino]-2-methylene-4-phenylbutyl ester
• CAS NO: 634600-99-0
• Molecular Formula: C26H33NO4
• Molecular Weight: 423.552
• Mol File: 634600-99-0.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: Benzenepropanoic acid, a-methyl-, 4-[[(1,1-dimethylethoxy)carbonyl]amino]-2-methylene-4-phenylbutyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Benzenepropanoic acid, a-methyl-, 4-[[(1,1-dimethylethoxy)carbonyl]amino]-2-methylene-4-phenylbutyl ester(634600-99-0)
• EPA Substance Registry System: Benzenepropanoic acid, a-methyl-, 4-[[(1,1-dimethylethoxy)carbonyl]amino]-2-methylene-4-phenylbutyl ester(634600-99-0)

Safety Data

• Hazardous Substances Data: 634600-99-0(Hazardous Substances Data)

Upstream product

• 81136-08-5 2-methyl-3-phenylpropanoyl chloride 
• 150884-50-7 benzaldehyde N-boc imine 
• 634600-98-9 2-methyl-3-phenylpropionic acid 2-trimethylsilanylmethylallyl ester 
• 4248-19-5 tert-butyl carbazate 

Downstream Products

• 634601-02-8 2-methyl-3-phenylpropionic acid 2-(2-benzylamino-2-phenylethyl)allyl ester 
• 634601-01-7 2-methyl-3-phenylpropionic acid 2-(2-amino-2-phenylethyl)allyl ester 

Relevant articles and documents

Solid-phase synthesis of 4-methylene pyrrolidines and allylic amines using palladium-activated allylic linkers

The solid-phase synthesis of 4-methylene pyrrolidines and allylic amines has been achieved using palladium-catalysed nucleophilic cleavage of allylic linkages. Six pyrrolidines were synthesised in five steps from a carboxyethyl resin 20, where the key transformations included a Lewis-acid promoted imino-Sakurai type reaction and reductive alkylation prior to the final palladium-catalysed cyclisation cleavage of the allylic carboxylate linkage. Allylic carboxylate resin 22 was also shown to undergo "traceless" cleavage using various hydride sources in the presence of catalytic palladium. A more robust allylic ether linkage was also investigated. Starting from a phenol resin 36, a number of 3-aryl-allylaniines were prepared using a palladium-catalysed nucleophilic cleavage reaction.