63487-16-1

Basic information

• Product Name: 2',4'-DIMETHOXYFLAVONE
• Synonyms: 2',4'-DIMETHOXYFLAVONE;2-(2,4-Dimethoxyphenyl)-4H-1-benzopyran-4-one
• CAS NO: 63487-16-1
• Molecular Formula: C₁₇H₁₄O₄
• Molecular Weight: 282.29
• Product Categories: Di-substituted Flavones
• Mol File: 63487-16-1.mol
• Article Data: 8

Chemical Properties

• Melting Point: 128-130°C
• Boiling Point: 446.7°C at 760 mmHg
• Flash Point: 199.4°C
• Appearance: /
• Density: 1.242g/cm³
• Vapor Pressure: 3.58E-08mmHg at 25°C
• Refractive Index: 1.598
• CAS DataBase Reference: 2',4'-DIMETHOXYFLAVONE(CAS DataBase Reference)
• NIST Chemistry Reference: 2',4'-DIMETHOXYFLAVONE(63487-16-1)
• EPA Substance Registry System: 2',4'-DIMETHOXYFLAVONE(63487-16-1)

Safety Data

• Hazardous Substances Data: 63487-16-1(Hazardous Substances Data)

Usage

General Description

2',4'-DIMETHOXYFLAVONE is a flavone compound that belongs to the class of organic compounds known as flavonoids. It is found in many plants and has been studied for its potential health benefits, including antioxidant and anti-inflammatory properties. This chemical has been shown to have potential neuroprotective and anti-cancer properties, making it a promising candidate for further research and development. It is also known to have antidiabetic, antiviral, and antibacterial effects, suggesting a wide range of potential therapeutic uses. Overall, 2',4'-DIMETHOXYFLAVONE is a natural compound with diverse biological activities that make it worthy of continued investigation.

InChI:InChI=1/C17H14O4/c1-19-11-7-8-13(16(9-11)20-2)17-10-14(18)12-5-3-4-6-15(12)21-17/h3-10H,1-2H3

Upstream product

• 491-37-2 2,3-dihydro-4H-1-benzopyran-4-one 
• 214360-69-7 4,4,5,5-tetramethyl-2-(2,4-dimethoxyphenyl)-1,3,2-dioxaborolane 
• 491-38-3 1-benzopyran-4(4H)-one 
• 17715-69-4 1-Bromo-2,4-dimethoxybenzene 
• 118-93-4 o-hydroxyacetophenone 
• 613-45-6 2,4-Dimethoxybenzaldehyde 
• 1776-08-5 (E)-3-(dimethylamino)-1-(2-hydroxyphenyl)prop-2-en-1-one 
• 133730-34-4 2,4-dimethoxyphenylboronic acid 
• 36685-63-9 (E)-2,4-dimethoxy-2'-hydroxychalcone 
• 98583-84-7 2-(2,4-dimethoxyphenyl)-2,3-dihydro-4H-chromen-4-one 

Downstream Products

• 170310-00-6 2’,4’-dihydroxyflavone 
• 77298-66-9 7,2'-dihydroxyflavone 

Relevant articles and documents

Water-mediated phosphorylative cyclodehydrogenation: An efficient preparation of flavones and flavanones

A new synthetic strategy utilizing POCl3-water for the conversion of 2′-hydroxychalcones to flavanones and flavones has been developed. The reagent efficiently promoted one-pot conversion of 2′-hydroxychalcones to flavones through flavanones involving cyclization and oxidative dehydrogenation. By changing the stoichiometery of the reagents, the reaction can be tuned to generate either flavanone or flavone. The developed protocol was found to be applicable for a variety of 2′-hydroxychalcones.

A versatile approach to flavones via a one-pot Pd(II)-catalyzed dehydrogenation/oxidative boron-Heck coupling sequence of chromanones

A variety of flavones were expediently synthesized from readily accessible chromanones via a one-pot sequence involving Pd(ii)-catalyzed dehydrogenation and oxidative boron-Heck coupling with arylboronic acid pinacol esters. In particular, the use of arylboronic acid pinacol esters was found to significantly improve the yield of the reaction.

Cyclization of 2'-hydroxychalcones to flavones using ammonium iodide as an iodine source - An eco-friendly approach

Ammonium iodide on exposure to air decomposes to ammonia and iodine. The in situ generated iodine was used for the cyclization of 2'-hydroxychalcones to the corresponding flavones under solvent-free conditions in good to excellent yields. This method could serve as an attractive alternative to the existing methods for synthesis of flavones and the use of toxic molecular iodine is avoided. Copyright