635311-89-6

Basic information

• Product Name: S-(4-fluorophenyl)-S-Methyl-SulfoxiMine
• Synonyms: S-(4-fluorophenyl)-S-Methyl-SulfoxiMine;1-Fluoro-4-(S-methylsulfonimidoyl)benzene;S-METHYL-S-(4-FLUOROPHENYL)SULFOXIMINE(WXC08964)
• CAS NO: 635311-89-6
• Molecular Formula: C₇H₈FNOS
• Molecular Weight: 173.2079232
• Mol File: 635311-89-6.mol
• Article Data: 12

Chemical Properties

• Melting Point: 93-94 °C(Solv: ethyl acetate (141-78-6))
• Boiling Point: 233.3±42.0 °C(Predicted)
• Appearance: /
• Density: 1.25±0.1 g/cm3(Predicted)
• CAS DataBase Reference: S-(4-fluorophenyl)-S-Methyl-SulfoxiMine(CAS DataBase Reference)
• NIST Chemistry Reference: S-(4-fluorophenyl)-S-Methyl-SulfoxiMine(635311-89-6)
• EPA Substance Registry System: S-(4-fluorophenyl)-S-Methyl-SulfoxiMine(635311-89-6)

Safety Data

• Statements: 20/21/22-37/38-48
• Safety Statements: 22-26-7/8-36/37/39-45
• Hazardous Substances Data: 635311-89-6(Hazardous Substances Data)

Upstream product

• 371-15-3 p-fluorothioanisole 
• 658-14-0 4-fluorophenyl methyl sulfoxide 

Downstream Products

• 635311-88-5 C₁₃H₂₂FNOSSi 

Relevant articles and documents

Nickel-Catalyzed N-Arylation of NH-Sulfoximines with Aryl Halides via Paired Electrolysis

A novel strategy for the N-arylation of NH-sulfoximines has been developed by merging nickel catalysis and electrochemistry (in an undivided cell), thereby providing a practical method for the construction of sulfoximine derivatives. Paired electrolysis is employed in this protocol, so a sacrificial anode is not required. Owing to the mild reaction conditions, excellent functional group tolerance and yield are achieved. A preliminary mechanistic study indicates that the anodic oxidation of a NiII species is crucial to promote the reductive elimination of a C?N bond from the resulting NiIII species at room temperature.

Palladium-Catalyzed Oxidative Annulation of Sulfoximines and Arynes by C-H Functionalization as an Approach to Dibenzothiazines

This work reports a novel and efficient palladium-catalyzed synthesis of tricyclic dibenzothiazines using easily prepared aryl sulfoximines and aryne precursors via C-H functionalization and cyclization. A mechanistic investigation indicated that the C-H bond cleavage at the position ortho to the sulfoximine group is the rate-determining step.

Method for synthesizing sulfoximine compounds from thioether

The invention discloses a synthetic method for synthesizing sulfoximine compounds from thioether in one step and application thereof. The synthetic method disclosed by the invention comprises the step of mixing the thioether, an ammonia source and an organic solvent together for carrying out an oxidizing reaction in the presence of an oxidizing agent, thereby obtaining the corresponding sulfoximine compounds. According to the invention, one-step synthesis of the sulfoximine compounds from the thioether is realized for the first time. In recent years, the sulfoximine structure is introduced into the existing drug molecules or high-activity compound molecules, and many high-activity molecules at the clinical stage and listed drug molecules appear. According to the method disclosed by the invention, the drug molecules containing the sulfoximine structure are produced, and the industrial cost can be greatly reduced; and moreover, the synthetic method provided by the invention has the advantages of being high in yield, readily available in raw materials, simple in conditions, simple in reaction equipment, easy in industrialized production, and the like. The structural formula is as shown in the specification.