636-54-4 Usage
Chemical Properties
White or almost white, hygroscopic, crystalline powder
Originator
Brinaldix,Novartis
Uses
Different sources of media describe the Uses of 636-54-4 differently. You can refer to the following data:
1. Antihypertensive; diuretic.
2. Antihypertensor;Gonad stimuling agent
3. Clopamide is a thiazide-like diuretic that inhibits sodium/chloride cotransporters in the proximal convoluted tubule of the kidney, which prevents the reabsorption of sodium and chloride. This compound is intended for research purposes only.
Manufacturing Process
To a solution of 5.5 g of 3-chlorsulfonyl-4-chlorobenzoylchloride in 20 ml
chlorobenzole 3.3 g of 1-amino-cis-2,6-dimethylpiperidin-hydrochloride slowly
was added at room temperature. Reaction mixture was heated to 100°-105°C
during 8 h, then it was cooled to room temperature. The precipitated crystals
of N-[cis-2,6-dimethyl-piperidyl-(1)]-3-chlorsulfonyl-4-chlorobenzoylamide
were filtered and dried at 100°C under vacuo, then was treated by ammonium
at room temperature. The obtained product was chromatographed (aluminum
oxide; eluent: chloroform-methanol 9:1 and methanol-ether) to give N-[cis-
2,6-dimethylpiperidyl-(1)]-3-sulfamyl-4-chlorbenzoylamide, melting point
235°-237°C.
Brand name
Aquex (Novartis).
Therapeutic Function
Diuretic, Antihypertensive
Check Digit Verification of cas no
The CAS Registry Mumber 636-54-4 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 6,3 and 6 respectively; the second part has 2 digits, 5 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 636-54:
(5*6)+(4*3)+(3*6)+(2*5)+(1*4)=74
74 % 10 = 4
So 636-54-4 is a valid CAS Registry Number.
InChI:InChI=1/C14H20ClN3O3S/c1-9-4-3-5-10(2)18(9)17-14(19)11-6-7-12(15)13(8-11)22(16,20)21/h6-10H,3-5H2,1-2H3,(H,17,19)(H2,16,20,21)/t9-,10+
