636-67-9Relevant articles and documents
Synthesis of Two Epimers of Pseudopaline
Arnoux, Pascal,Cavelier, Florine,Cullia, Gregorio,Fanelli, Roberto,Voulhoux, Romé
supporting information, (2020/07/06)
Opines are a known group of compounds characterized by an elevated polarity. Recently, two new members of this class, staphylopine and pseudopaline, have been identified in Staphylococcus aureus and Pseudomonas aeruginosa, respectively. These molecules are metal chelators that contribute to the growth of bacteria in particularly metal-poor environment. Different evidences suggest that these molecules might have an important role in the development of pulmonary infections in humans. Considering the impact of P. aeruginosa infections in cystic fibrosis patients (prevalence up to 70 percent), pseudopaline has risen interest as potential source of new therapeutic intervention. We present herein a straightforward synthetic approach for the synthesis of the two epimers of pseudopaline. Starting from a chiral building block, we attribute the absolute configuration to the two obtained diasteroisomers.
CONVERSION OF 1,2,5,6-HEXANETETROL (HTO) TO TETRAHYDROFURAN DICARBOXYLIC ACID (THFDCA)
-
Paragraph 46, (2019/11/04)
Disclosed herein are methods for synthesizing useful intermediates and/or products from 1,2,5,6-hexanetetrol (HTO), which itself can be derived from a sugar. In an aspect, a process is provided for production of THFDCA from 1,2,5,6-hexanetetrol (HTO). The process comprises the steps of (a) ring closing to form a ring compound and (b) oxidizing using a catalyst comprising platinum and bismuth to form an acid mixture. Step (a) may be performed before or after step (b).
Hydrothermal conversion of macroalgae-derived alginate to lactic acid catalyzed by metal oxides
Jeon, Wonjin,Ban, Chunghyeon,Park, Geonu,Woo, Hee Chul,Kim, Do Heui
, p. 1146 - 1156 (2016/02/27)
Alginate derived from macroalgae was evaluated as a biomass feedstock for the production of lactic acid using metal oxides as solid base catalysts under hydrothermal conditions. The CaO catalyst exhibited the highest catalytic performance, yielding about 13% lactic acid at 200°C for 1 h, while other metal oxide catalysts exhibited little activity. The hydration of CaO to Ca(OH)2 provides Br?nsted bases (OH-) in an aqueous medium. The lactic acid yields were proportional to the number of Br?nsted bases. The CaO catalyst demonstrated nearly similar activity when it was used for the second time and the spent catalyst was successfully regenerated by calcination. The deactivation of the CaO catalyst during subsequent repeated uses arises from the loss of the available basic sites. Plausible reaction pathways for the catalytic conversion of alginate to lactic acid over CaO are also discussed.
