6375-47-9Relevant articles and documents
Hydrogenation of 3-nitro-4-methoxy-acetylaniline with H2 to 3-amino-4-methoxy-acetylaniline catalyzed by bimetallic copper/nickel nanoparticles
Yang, Chenchen,Xue, Wuping,Yin, Hengbo,Lu, Zhipeng,Wang, Aili,Shen, Lingqin,Jiang, Yunyan
, p. 3358 - 3366 (2017)
Monometallic Cu, monometallic Ni, and bimetallic CuxNiy nanoparticles were prepared by a wet chemical reduction method. A Cu-Ni alloy phase was formed in the bimetallic CuxNiy nanoparticles. The bimetallic CuxNiy nanoparticles exhibited higher catalytic activity for the hydrogenation of 3-nitro-4-methoxy-acetylaniline (NMA) to 3-amino-4-methoxy-acetylaniline (AMA) with H2 than the sole Ni nanoparticles, which was ascribed to the effect of the Cu-Ni alloy phase. When the reaction was catalyzed over the bimetallic Cu0.7Ni0.3 catalyst at 140 °C for 2 h, the AMA selectivity was 99.4% when the NMA conversion was 95.7%. The reaction activation energy for NMA hydrogenation was 19.74 kJ mol-1.
2 - Amino - 4 - acetamido anisole novel synthesis process (by machine translation)
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Paragraph 0065-0066, (2018/03/01)
The present invention provides a novel 2 - amino - 4 - acetamido anisole synthesis process, the usage of palladium bi-metal catalysts and the palladium/carbon catalyst to replace Rany - Ni catalyst, to the anisole on the nitro-selective catalytic hydrogenation, which not only reduces use Rany - Ni catalyst of post-industrial risks, while at the same time, the resulting 2 - amino - 4 - acetyl anisole purity higher, greater yield. (by machine translation)
Industrial production method for 2-amino-4-acetamidoanisole
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Paragraph 0055; 0061, (2018/04/03)
The invention discloses an industrial production method for 2-amino-4-acetamidoanisole. The industrial production method comprises the following steps: (1) allowing paranitroanisole and hydrogen to undergo a catalytic hydrogenation reduction reaction in the presence of a catalyst A so as to obtain p-aminoanisole; (2) allowing the p-aminoanisole to undergo an acetylation reaction so as to obtain p-acetamidoanisole; (3) allowing the p-acetamidoanisole to undergo a nitration reaction so as to obtain 2-nitro-4-acetamidoanisole; and (4) allowing 2-nitro-4-acetamidoanisole and hydrogen to undergo two catalytic hydrogenation reduction reactions in the presence of a catalyst B so as to obtain the 2-amino-4-acetamidoanisole. The production method provided by the invention has the characteristics oflow production cost, high reaction selectivity, simple separation process, high product purity, no three wastes in the process of production, recyclability and continuous large-scale industrial production, and solves the disadvantages of high separation cost, low product purity, and large discharge amount and difficult treatment of three wastes in the prior art.