63767-58-8

Basic information

• Product Name: ETHYL 3-(4-METHOXYANILINO)PROPANOATE
• Synonyms: ETHYL 3-(4-METHOXYANILINO)PROPANOATE;ETHYL 3-(4-METHOXYANILINO)PROPIONATE;4-Methoxy-N-[2-(ethoxycarbonyl)ethyl]aniline;N-(4-Methoxyphenyl)-beta-alanine ethyl ester;3-(4-Methoxy-phenylamino)-propionic acid ethyl ester
• CAS NO: 63767-58-8
• Molecular Formula: C₁₂H₁₇NO₃
• Molecular Weight: 223.27
• Mol File: 63767-58-8.mol
• Article Data: 22

Chemical Properties

• Appearance: /
• CAS DataBase Reference: ETHYL 3-(4-METHOXYANILINO)PROPANOATE(CAS DataBase Reference)
• NIST Chemistry Reference: ETHYL 3-(4-METHOXYANILINO)PROPANOATE(63767-58-8)
• EPA Substance Registry System: ETHYL 3-(4-METHOXYANILINO)PROPANOATE(63767-58-8)

Safety Data

• Hazardous Substances Data: 63767-58-8(Hazardous Substances Data)

Upstream product

• 104-94-9 4-methoxy-aniline 
• 140-88-5 ethyl acrylate 
• 623-47-2 propynoic acid ethyl ester 
• 100-17-4 para-methoxynitrobenzene 
• 105-56-6 ethyl 2-cyanoacetate 
• 33604-68-1 p-Methoxyphenyldiazo-p'-methylphenylsulfon 
• 911641-23-1 bis(2-carboethoxyethyl)zinc 
• 36320-66-8 3-Rhodanopropionsaeureethylester 
• 64-19-7 acetic acid 

Downstream Products

• 1150-26-1 N-(4-Methoxy-phenyl)-4-methyl-benzenesulfonamide 
• 75227-41-7 N-tosyl-6-methoxy-2,3-dihydroquinolin-4-one 
• 6945-33-1 3-[N-(4-methoxyphenyl)(p-toluene)sulfonamido]propanoic acid 
• 637038-54-1 3-[N-(4-methoxyphenyl)(p-toluene)sulfonamido]propanoyl chloride 
• 76263-68-8 6-Methoxy-3-[1-phenyl-meth-(E)-ylidene]-1-(toluene-4-sulfonyl)-2,3-dihydro-1H-quinolin-4-one 
• 76263-73-5 1-[(3S,3aR)-8-Methoxy-3-phenyl-5-(toluene-4-sulfonyl)-3,3a,4,5-tetrahydro-pyrazolo[4,3-c]quinolin-2-yl]-ethanone 
• 890841-64-2 N-benzyl-6-methoxy-2,3-dihydroquinolin-4-one 

Relevant articles and documents

Synthesis of 2,3-Dihydro-4-pyridones and 4-Pyridones by the Cyclization Reaction of Ester-Tethered Enaminones

2,3-Dihydro-4-pyridone skeleton is an important building block in organic synthesis because it features several reaction sites with nucleophilic or electrophilic properties. Herein, we disclose a method for its formation by intramolecular cyclization of ester-tethered enaminones, which can easily be synthesized from readily available materials, such as amines, activated alkynes, and activated alkenes. 2,3-Dihydro-4-pyridones have been isolated in 41-90% yields. We also demonstrate the transformation of these heterocycles into another important class of compounds, 4-pyridones, by utilizing 2,3,5,6-tetrachloro-p-benzoquinone (chloranil) as an oxidizing agent. The latter products were isolated in 65-94% yields.

Preparation method of 3-(phenyl amino)ethyl propionate type compound

The invention belongs to the technical field of chemical synthesis and particularly relates to a preparation method of a 3-(phenyl amino)ethyl propionate type compound. The method is realized throughthe following steps: mixing an aromatic amine compound w

Tin-Catalyzed Selective Reductive Hydroamination of Alkynes for the Synthesis of Tertiary Amines

A unique preference of tin(II) for aniline activation is disclosed. In the present work tin(II) triflate-catalyzed highly selective Markovnikov reductive hydroamination of internal as well as terminal alkynes is reported. The mechanistic study revealed the involvement of two steps in one pot wherein alkyne reduces to corresponding alkene in presence of PMHS as reducing agent followed by hydroamination of alkene. A broad range of alkynes transformed into tertiary amines with good to excellent yield. This method is equally applicable in synthesis of secondary amines.