63777-68-4

Basic information

• Product Name: 1-phenethyl-1H-benzo[d][1,2,3]triazole
• Synonyms: 1-phenethyl-1H-benzo[d][1,2,3]triazole
• CAS NO: 63777-68-4
• Molecular Weight: 223.277
• Mol File: 63777-68-4.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: 1-phenethyl-1H-benzo[d][1,2,3]triazole(CAS DataBase Reference)
• NIST Chemistry Reference: 1-phenethyl-1H-benzo[d][1,2,3]triazole(63777-68-4)
• EPA Substance Registry System: 1-phenethyl-1H-benzo[d][1,2,3]triazole(63777-68-4)

Safety Data

• Hazardous Substances Data: 63777-68-4(Hazardous Substances Data)

Usage

Classification

Aromatic heterocyclic compound.

Structure

Composed of a benzene ring fused to a 1,2,3-triazole ring and a phenethyl group.

Research applications

Widely used in neuroscience research.

Function

Potent and selective P2X7 receptor agonist.

Biological role

P2X7 receptors are involved in the regulation of immune responses and inflammation.

Therapeutic potential

Possible treatment for chronic pain, neuroinflammation, and neurodegenerative disorders.

Upstream product

• 13351-73-0 1-methyl-1H-benzo[d][1,2,3]triazole 
• 100-39-0 benzyl bromide 
• 95-14-7 1,2,3-Benzotriazole 
• 103-63-9 1-phenyl-2-bromoethane 
• 88-73-3 2-Chloronitrobenzene 
• 1449418-23-8 1-(2-phenyl-2-((2,2,6,6-tetramethylpiperidin-1-yl)oxy)ethyl)-1H-benzo[d][1,2,3]triazole 
• 64-04-0 phenethylamine 
• 100870-32-4 N-(2-Phenylethyl)-2-nitroaniline 
• 147861-08-3 1-iodomethylbenzotriazole 
• 54187-96-1 1-(chloromethyl)-1H-benzotriazole 
• 100-44-7 benzyl chloride 
• 111198-18-6 1-((phenylsulfinyl)methyl)-1H-benzo[d][1,2,3]triazole 
• 41625-94-9 N-(2-phenylethyl)-2-aminoaniline 
• 19213-23-1 1-((pyrrolidin-1-yl)methyl)-1H-benzo[d][1,2,3]triazole 

Relevant articles and documents

Stereoselective radical azidooxygenation of alkenes

Radical azidooxygenation of various alkenes is described. A readily prepared N3-iodine(III) reagent acts as a clean N3-radical precursor. Radical generation is achieved with TEMPONa acting as a mild organic reducing reagent. The C-radical generated after N3-radical addition is efficiently trapped by in situ generated TEMPO. Yields are good to excellent, and for cyclic systems azidooxygenation occurs with excellent diastereoselectivity.

A Novel Selective Route to 1-Substituted Benzotriazoles via Lithiation of Simple 1-Alkylbenzotriazoles

1-Methylbenzotriazole (2a) is lithiated readily with butyllithium or LDA at the methyl group to 4 and the subsequent reaction with various electrophiles provides 1-substituted benzotriazoles 5.Other 1-(n-alkyl)benzotriazoles 2 also undergo lithiation with LDA, the carbanions can be trapped with alkyl halides giving benzotriazoles 6 bearing secondary alkyl groups on the N-1 atom.On standing in the absence of electrophiles, all the lithium derivatives decompose to afford complex mixtures. - Key Words: Benzotriazoles, 1-alkyl / Lithiation / Haloalkanes

Reactions of 1-(α-Alkoxyalkyl)- and 1-(α-(Aryloxy)alkyl)benzotriazoles with the Grignard Reagents. A New and Versatile Method for the Preparation of Ethers

1-(α-Alkoxyalkyl)benzotriazoles deriving from aldehydes (other than formaldehyde), or from ketones, react with Grignard reagents at 110 deg C to provide a high-yielding, general synthesis of dialkyl and aryl ethers.Under similar conditions, 1-(alkoxymethyl)- and 1-((aryloxy)methyl)benzotriazoles give, by a different cleavage pattern of the N-C-O grouping, 1-alkylbenzotriazoles and N,N'-dialkyl-o-phenylenediamines.The 1-(α-alkoxyalkyl)benzotriazoles are easily prepared: (a) by condensation of benzotriazole, an aldehyde, and an alcohol under water-removing conditions; (b) by condensation of a 1-(α-chloroalkyl)benzotriazole with a sodium or potassium alkoxide or aryloxide; and (c) by condensatioon of an acetal or a ketal with benzotriazole.All the 1-(α-alkoxyalkyl)benzotriazoles and dialkyl or alkyl aryl ethers obtained were fully characterized by their 1H and 13C NMR spectra.