639011-64-6

Basic information

• Product Name: 3-BROMO-5-(2-TRIMETHYLSILYL)ETHYNYL)PYRIDINE
• Synonyms: 3-BROMO-5-(2-TRIMETHYLSILYL)ETHYNYL)PYRIDINE;3-BroMo-5-[(triMethylsilanyl)ethynyl]pyridine;Pyridine,3-bromo-5-[2-(trimethylsilyl)ethynyl]-
• CAS NO: 639011-64-6
• Molecular Formula: C₁₀H₁₂BrNSi
• Molecular Weight: 254.19848
• Mol File: 639011-64-6.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 261.4±40.0 °C(Predicted)
• Appearance: /
• Density: 1.28±0.1 g/cm3(Predicted)
• PKA: 2.42±0.22(Predicted)
• CAS DataBase Reference: 3-BROMO-5-(2-TRIMETHYLSILYL)ETHYNYL)PYRIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-BROMO-5-(2-TRIMETHYLSILYL)ETHYNYL)PYRIDINE(639011-64-6)
• EPA Substance Registry System: 3-BROMO-5-(2-TRIMETHYLSILYL)ETHYNYL)PYRIDINE(639011-64-6)

Safety Data

• Hazardous Substances Data: 639011-64-6(Hazardous Substances Data)

Usage

General Description

3-Bromo-5-(2-trimethylsilyl)ethynyl)pyridine is a complex chemical compound which may feature prominently in scientific and industrial applications. The molecular formula of this substance is C10H13BrNSi, highlighting the presence of bromine, nitrogen, silicon, hydrogen, and carbon in its composition. The chemical, by virtue of its potential reactivity, could be leveraged in a variety of chemical reactions or synthesis procedures. Due to its specific chemical structure, this chemical might be targeted for use in the fields of medicine, materials science or other high-tech industries. Nonetheless, handling and usage precautions are strongly recommended due to possible risks associated with its potentially reactive nature.

Upstream product

• 625-92-3 3,5-dibromopyridine 
• 1066-54-2 trimethylsilylacetylene 
• 1537918-38-9 3-bromo-5-(3-hydroxy-3-methyl-1-butynyl)pyridine 
• 233770-01-9 3-bromo-5-iodopyridine 

Downstream Products

• 1383744-40-8 C₁₆H₁₄BrF₂N₅O₂S 
• 1314325-33-1 (S)-2-(5-trimethylsilylethynylpyridin-3-yl)pyrrolidine-1-carboxylic acid tert-butyl ester 
• 866683-52-5 3-bromo-5-ethynylpyridine 

Relevant articles and documents

Stabilization of a Self-assembled Coordination Nanotube by Covalent Link

A newly designed oligopyridine ligand in which two tris(3,5-pyridine) units are linked by an alkyl spacer is complexed with (en)Pd(NO 3)2 leading to the self-assembly of a coordination nanotube with an empty cavity. The covalent link in the ligand considerably stabilizes the tube because the tube framework without the covalent link does not assemble unless a template is employed. Size-discriminated alkane inclusion by the tube is also disclosed.

NEW TRIAZOLYLPHENYL SULFONAMIDES AS SERINE/THREONINE KINASE INHIBITORS

The present invention encompasses compounds of general formula (I) wherein the groups R2 to R4, A,X and m are defined as in claim 1, which are suitable for the treatment of diseases characterised by excessive or abnormal cell proliferation, pharmaceutical preparations which contain compounds of this kind and their use as medicaments.

Enantioselective, palladium-catalyzed α-arylation of N-Boc pyrrolidine: In situ react IR spectroscopic monitoring, scope, and synthetic applications

A comprehensive study of the enantioselective Pd-catalyzed α-arylation of N-Boc pyrrolidine has been carried out. The protocol involves deprotonation of N-Boc pyrrolidine using s-BuLi/(-)-sparteine in TBME or Et2O at -78 °C, transmetalation with ZnCl2 and Negishi coupling using Pd(OAc)2, t-Bu3P-HBF4 and the aryl bromide. This paper reports several new features including in situ React IR spectroscopic monitoring of the process; use of (-)-sparteine and the (+)-sparteine surrogate to access products with opposite configuration; development of a catalytic asymmetric lithiation-Negishi coupling reaction; extension to a wide range of heteroaromatic bromides; total synthesis of (R)-crispine A, (S)-nicotine and (S)-SIB-1508Y via short synthetic routes; and examples of α-vinylation of N-Boc pyrrolidine using vinyl bromides exemplified by the total synthesis of naturally occurring (+)-maackiamine (thus establishing its configuration as (R)). In this way, the full scope and limitations of the methodology are delineated.