63910-43-0

Basic information

• Product Name: 4-CHLORO-5-METHOXYPYRIDAZIN-3(2H)-ONE
• Synonyms: 4-CHLORO-5-METHOXYPYRIDAZIN-3(2H)-ONE;AURORA KA-6685;4-Chloro-2,3-dihydro-5-methoxy-3-oxopyridazine;5-chloro-4-methoxy-1H-pyridazin-6-one;4-Chloro-5-methoxy-3(2H)-pyridazinone;4-chloro-5-methoxy-2,3-dihydropyridazin-3-one
• CAS NO: 63910-43-0
• Molecular Formula: C₅H₅ClN₂O₂
• Molecular Weight: 160.56
• Product Categories: Pyrazines, Pyrimidines & Pyridazines;Pyrazines, Pyrimidines & Pyridazines
• Mol File: 63910-43-0.mol
• Article Data: 6

Chemical Properties

• Melting Point: 225 °C(dec.)
• Appearance: /
• Density: 1.51 g/cm³
• Refractive Index: 1.59
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• CAS DataBase Reference: 4-CHLORO-5-METHOXYPYRIDAZIN-3(2H)-ONE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-CHLORO-5-METHOXYPYRIDAZIN-3(2H)-ONE(63910-43-0)
• EPA Substance Registry System: 4-CHLORO-5-METHOXYPYRIDAZIN-3(2H)-ONE(63910-43-0)

Safety Data

• Hazardous Substances Data: 63910-43-0(Hazardous Substances Data)

Usage

General Description

4-CHLORO-5-METHOXYPYRIDAZIN-3(2H)-ONE, also known as Clomazone, is a chemical compound commonly used as an herbicide to control the growth of grasses and broadleaf weeds in agricultural crops. It belongs to the chemical class of pyridazinones and acts by inhibiting the biosynthesis of carotenoids in the targeted plants, thus disrupting their photosynthetic processes and ultimately leading to their death. Clomazone is typically applied as a pre-emergent herbicide, meaning it is used to prevent the germination and growth of weeds before they become established in the soil. Its selective mode of action and relatively low toxicity to non-target organisms make it a popular choice for weed control in various crops, including cotton, soybeans, and peanuts. However, it is important to use this chemical with caution and according to label instructions to minimize potential environmental and health risks.

InChI:InChI=1/C5H5ClN2O2/c1-10-3-2-7-8-5(9)4(3)6/h2H,1H3,(H,8,9)

Upstream product

• 637-89-8 4-sulfanylphenol 
• 859214-49-6 2-cyano-4-chloro-5-methoxypyridazin-3(2H)-one 
• 3886-69-9 (R)-1-phenyl-ethyl-amine 
• 108-91-8 cyclohexylamine 
• 62-53-3 aniline 
• 1193-02-8 4-aminotiophenol 
• 124-41-4 sodium methylate 
• 932-22-9 4,5-Dichloro-3-hydroxypyridazine 
• 93-91-4 1-phenylbutan-1,3-dione 
• 100-46-9 benzylamine 
• 103-67-3 benzyl-methyl-amine 
• 67-56-1 methanol 
• 932-22-9 4,5-dichloro-2H-pyridazin-3-one 

Downstream Products

• 186142-39-2 2-(2,5-difluoro-4-cyano-phenyl)-4-chloro-5-methoxy-pyridazin-3-one 
• 1036934-84-5 4-chloro-5-methoxy-2-(β-trifluoro)ethyl-3(2H)-pyridazinone 
• 14628-57-0 4-chloro-5-methoxy-2-methyl-2H-pyridazin-3-one 
• 123696-02-6 3-chloro-5-methoxy-pyridazine 
• 20733-11-3 4-methoxypyridazine 
• 63910-32-7 3,4-dichloro-5-methoxy-pyridazine 
• 64178-58-1 4-chloro-5-hydroxy-3(2H)-pyridazinone 
• 123696-01-5 3-methoxy-3(2H)-pyridazinone 

Relevant articles and documents

Propionic Acid Derivatives and Methods of Use Thereof

Provided herein are compounds and pharmaceutical compositions of formula I where R1, R2, R3, R4, R5 and R6 are as described herein. Also provided pharmaceutically acceptable salts or stereoisomers of these compounds. In addition methods are provided for inhibiting the binding of an integrin to treat various pathophysiological conditions.

2-Cyanopyridazin-3(2H)-ones: Effective and chemoselective electrophilic cyanating agents

2-Cyanopyridazin-3(2H)-ones are novel, effective, selective and electrophilic cyanating agents. A variety of amino, thiol and carbon nucleophiles are chemoselectively N-, S- or C-cyanated in excellent yield using 2-cyanopyridanzin-3(2H)-ones in water or tetrahydrofuran.

Direct functionalization of 4,5-dichloropyridazin-6-one

Direct functionalization of 4,5-dichloropyridazin-6-one with some nucleophiles in seven solvents gave regioselectively 5-halo- 4-substituted-pyridazin-6-ones as main product. Reaction of 4,5- dichloropyridazin-6-one with 2-mercaptopyrimidine (2 equivalents) also afforded 4,5-di(pyrimidin-2-ylsulfanyl)pyridazin-6-one as the main product.