64098-32-4

Basic information

• Product Name: zapizolam
• Synonyms: zapizolam;8-Chloro-6-(2-chlorophenyl)-4H-pyrido[2,3-f][1,2,4]triazolo[4,3-a][1,4]diazepine;D-13129;4H-Pyrido[2,3-f][1,2,4]triazolo[4,3-a][1,4]diazepine, 8-chloro-6-(2-chlorophenyl)-
• CAS NO: 64098-32-4
• Molecular Formula: C₁₅H₉Cl₂N₅
• Molecular Weight: 330.177
• EINECS: 264-670-8
• Mol File: 64098-32-4.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 546.2°C at 760 mmHg
• Flash Point: 284.1°C
• Appearance: /
• Density: 1.58g/cm³
• Vapor Pressure: 5.49E-12mmHg at 25°C
• Refractive Index: 1.773
• CAS DataBase Reference: zapizolam(CAS DataBase Reference)
• NIST Chemistry Reference: zapizolam(64098-32-4)
• EPA Substance Registry System: zapizolam(64098-32-4)

Safety Data

• Hazardous Substances Data: 64098-32-4(Hazardous Substances Data)

Usage

General Description

Zapizolam is a psychoactive drug that belongs to the class of benzodiazepines. It acts as a positive allosteric modulator of the GABA-A receptor, leading to enhanced inhibitory neurotransmission in the central nervous system. This results in sedative, anxiolytic, muscle relaxant, and hypnotic effects. Zapizolam has been used for the short-term treatment of insomnia and anxiety disorders, as well as for its anxiolytic and sedative properties. However, due to its potential for abuse, tolerance, and dependence, its use is generally limited to short-term therapy, and caution is advised when prescribing it. It has also been withdrawn from the market in several countries due to safety concerns.

InChI:InChI=1/C15H9Cl2N5/c16-10-4-2-1-3-9(10)14-15-11(5-6-12(17)20-15)22-8-19-21-13(22)7-18-14/h1-6,8H,7H2

Upstream product

• 64098-30-2 8-chloro-6-(2-chloro-phenyl)-4H-benzo[f][1,2,4]triazolo[4,3-a][1,4]diazepine 5-oxide 

Relevant articles and documents

6-Aryl-s-triazolo-(4,3-a)-pyrido-(2,3-f)-1,4-diazepines

There are produced 6-aryl-s-triazolo-(4,3-a)-pyrido-(2,3-f)-(1,4)-diazepines of the formula: STR1 wherein R1 is hydrogen, a halogen atom, an alkyl group with 1 to 6 carbon atoms, a hydroxy group, an alkoxy group with 1 to 6 carbon atoms, a mercapto group, an alkyl mercapto group having 1 to 6 carbon atoms, an alkylsulfoxido group with 1 to 6 carbon atoms, an alkyl sulfono group with 1 to 6 carbon atoms, an amino group, an aliphatic acylamino group with 2 to 6 carbon atoms, a monoalkylamino group with 1 to 6 carb0n atoms, a dialkylamino group with 1 to 6 carbon atoms in each alkyl group or a saturated heterocyclic amino group having 5 to 7 members in the ring including 1 to 2 nitrogen atoms and 0 to 1 oxygen atoms in the ring, R2 is hydrogen, an alkyl group with 1 to 6 carbon atoms, a hydroxy group, an acyloxy group with 2 to 6 carbon atoms, an alkoxy group with 1 to 6 carbon atoms, a mercapto group, an alkylmercapto group with 1 to 6 carbon atoms, a halogen atom, an amino group, an aliphatic acylamino group with 2 to 6 carbon atoms, a monoalkylamino group with 1 to 6 carbon atoms, a dialkylamino group with 1 to 6 carbon atoms in each alkyl group or a saturated heterocyclic amino group having 5 to 7 members in the ring including 1 to 2 nitrogen atoms and 0 to 1 oxygen atoms in the ring, R3 is hydrogen, an alkyl group with 1 to 6 carbon atoms, an alkoxy group with 1 to 6 carbon atoms or a halogen atom, The structural part A--B is the group --N=N--, --CH2 --NH--, --CO--NR4, --C(SR5)=N--, --C(OR5)=N--, --C(NR5 R5)=N--, or --CR6 =N--, wherein R4 is hydrogen, an alkenyl group with 2 to 6 carbon atoms, an alkinyl group with 2 to 6 carbon atoms, a hydroxy-alkyl group with 1 to 6 carbon atoms, a ketoalkyl group with 1 to 6 atoms in the alkyl group, a cyanoalkyl group with 1 to 6 carbon atoms, an alkyl group with 1 to 6 carbon atoms, or an alkyl group of 1 to 6 carbon atoms substituted by an alkoxy group with 1 to 6 carbon atoms, a dialkylamino group with 1 to 6 carbon atoms in each alkyl group or a saturated heterocyclic amino group having 5 to 7 members in the ring including 1 to 2 nitrogen atoms and 0 to 1 oxygen atoms, R5 is hydrogen or an alkyl group with 1 to 6 carbon atoms, R6 is hydrogen, an alkyl group with 1 to 6 carbon atoms or a haloalkyl group with 1 to 6 carbon atoms, And Y--Z is the group >CH=N--, >C=N(→O), >CH--NH-- or >CH--N(OH)-- and wherein R6 is other than alkyl if R1 is chlorine, R2 is hydrogen, R3 is hydrogen or halogen and Y-Z is the group >C=N--, their optical isomers and their pharmaceutically acceptable salts. The compounds have anticonvulsive properties.