6419-36-9

Basic information

• Product Name: 3-Pyridylacetic acid hydrochloride
• Synonyms: PYRIDIN-3-YLACETIC ACID HYDROCHLORIDE;PYRIDINE-3-ACETIC ACID HYDROCHLORIDE;2-(3-Pyridinyl)acetic acid;3-Pyridylactic Acid Hydrochloride;3-(acety acid)pyridine hydrochloride;Pyridine-3-acetic acid hydrochloride, 98+%;Risedronate Sodium intermediate;3-(acetic acid)pyridine hydrochloride
• CAS NO: 6419-36-9
• Molecular Formula: C₇H₈NO₂*Cl
• Molecular Weight: 173.6
• EINECS: 229-148-6
• Product Categories: Pyridine series;Pyridine;Acids and Derivatives;Heterocycles;Carboxylic Acids;Pyridines;Organic acids;Pyridines derivates;API intermediates;(intermediate of risedronate sodium);Building Blocks;Pyridinium Compounds;Carboxylic Acids;Aromatics, Heterocycles, Metabolites & Impurities
• Mol File: 6419-36-9.mol
• Article Data: 6

Chemical Properties

• Melting Point: 161-163 °C(lit.)
• Boiling Point: 301.6 °C at 760 mmHg
• Flash Point: 136.2 °C
• Appearance: White to light yellow or beige/Crystalline Powder, Crystals and/or Chunks
• Vapor Pressure: 0.000463mmHg at 25°C
• Storage Temp.: Inert atmosphere,Room Temperature
• Solubility: DMSO (Sparingly), Methanol (Slightly)
• Stability: Hygroscopic
• Merck: 14,7971
• BRN: 3696630
• CAS DataBase Reference: 3-Pyridylacetic acid hydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Pyridylacetic acid hydrochloride(6419-36-9)
• EPA Substance Registry System: 3-Pyridylacetic acid hydrochloride(6419-36-9)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• WGK Germany: 3
• F: 10
• HazardClass: IRRITANT
• Hazardous Substances Data: 6419-36-9(Hazardous Substances Data)

Usage

Chemical Properties

white to beige crystalline powder

Uses

Different sources of media describe the Uses of 6419-36-9 differently. You can refer to the following data:
1. 3-Pyridylacetic Acid is a metabolite of Nicotine (N412420). 3-Pyridylacetic Acid is an antilipemic.
2. These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

General Description

Risedronate Impurity D is an impurity of risedronate, which is a new generation pyridinyl bisphosphonate, effectively used in the treatment of Paget′s disease of bone. It is also used for the treatment of skeletal disorders since it inhibits osteoclast-mediated bone resorption and modulates bone metabolism.

InChI:InChI=1/C7H7NO2/c9-7(10)4-6-2-1-3-8-5-6/h1-3,5H,4H2,(H,9,10)/p-1

Upstream product

• 110-91-8 morpholine 
• 350-03-8 methyl-3-pyridylketone 
• 5423-64-3 (pyridin-3-yl)thioacetmorpholide 
• 61494-55-1 2-Chloro-pyridin-3-yl acetic acid 
• 501-81-5 pyridyl-3-yl-acetic acid 
• 15504-40-2 3-(pyridin-3-yl)pyruvic acid 

Downstream Products

• 784987-54-8 1-benzyl-4-(pyridin-3-yl-acetyl)-piperazine 
• 899431-57-3 N-(2-chloro-4-fluoro-3-trifluoromethylphenyl)-2-pyridin-3-ylacetamide 
• 6293-56-7 3-pyridinylethanol 
• 4226-36-2 3-(2-chloroethyl)pyridine hydrochloride 
• 556825-56-0 3-(2-mercaptoethyl)pyridine 
• 558465-04-6 N-[[6-[(4-Chlorophenylsulfonyl)(2,5-difluorophenyl)methyl]pyridin-3-yl]methyl]-2-(pyridin-3-yl)acetamide 
• 146885-92-9 2-{(S)-3-[2-(2-Formyl-pyridin-3-yl)-ethyl]-2-oxo-oxazolidin-4-ylmethylene}-malonic acid di-tert-butyl ester 
• 146885-88-3 3-(2-Hydroxy-ethyl)-pyridine-2-carbonitrile 
• 146885-97-4 2-(1-Oxy-pyridin-3-yl)-ethanol 
• 145237-01-0 acromelic acid E 
• 86630-10-6 acromelic acid B 
• 126436-30-4 2-(4-acetylamino-2-methoxy-5-nitrophenyl)-1-hydroxy-4-methyl-5-(3-pyridyl)imidazole 
• 1026646-44-5 N-[5-(1-Hydroxy-4-methyl-5-pyridin-3-yl-1H-imidazol-2-yl)-2,4-dimethoxy-phenyl]-acetamide 
• 114989-71-8 2-(4-acetylamino-2-methoxy-5-nitrophenyl)-5-methyl-4-(3-pyridyl)imidazole 

Relevant articles and documents

Preparation method of 3-pyridylacetic acid hydrochloride

The invention discloses a preparation method of 3-pyridylacetic acid hydrochloride and belongs to the field of chemistry. A 3-pyridylacetic acid hydrochloride product is prepared from 3-methylpyridine chlorination side product 2-chloro-3-methylpyridine as a raw material through cyanidation, alkaline hydrolysis, hydrogenation reduction and salification. The 3-pyridylacetic acid hydrochloride product has purity of 98.5% or more.

Novel Process For Preparing Risedronic Acid

The present invention relates to a process for preparing risedronic acid comprising the step of combining a 3-pyridyl acetic acid or a salt thereof, phosphorous acid, and a halophosporous compound selected from PCl3, PClS, POCl3, PBr3, POBr3, and PBr5 in the presence of a diluent that is either a bicyclic aliphatic hydrocarbon or a substituted cyclic aliphatic hydrocarbon or a mixture thereof, in combination with a codiluent, that is orthophosphoric acid

Syntheses and UV/Vis-spectroscopic properties of hydrophilic 2-, 3-, and 4-pyridyl-substituted solvatochromic and halochromic pyridinium N-phenolate betaine dyes as new empirical solvent polarity indicators

Syntheses and negative solvatochromism of nine new hydrophilic 2-, 3-, and 4-pyridyl-substituted pyridinium N-phenolate betaine dyes 3-11 are described. These were produced in order to obtain zwitterionic dyes better soluble in water and other aqueous media (such as binary water/solvent mixtures, aqueous ionophore solutions) than the rather hydrophobic standard betaine dyes 1 and 2, which have been used to establish an empirical scale of solvent polarity, called the ET(30) scale. Betaine dye 8, in which three of the peripheral phenyl groups of 1 are replaced by two 3-pyridyl rings and one 4-pyridyl ring, proved to be particularly suitable for the determination of ET(30) values in aqueous media. Wiley-VCH Verlag GmbH, 2001.