64205-92-1

Basic information

• Product Name: 4,5-DIHYDRO-1H-IMIDAZOLE-2-SULFONIC ACID
• Synonyms: 4,5-DIHYDRO-1H-IMIDAZOLE-2-SULFONIC ACID;1H-Imidazole-2-sulfonic acid, 4,5-dihydro-
• CAS NO: 64205-92-1
• Molecular Formula: C₃H₆N₂O₃S
• Molecular Weight: 150.16
• Mol File: 64205-92-1.mol
• Article Data: 1

Chemical Properties

• Melting Point: 140-145 °C
• Appearance: /
• Density: 1.89 g/cm³
• Refractive Index: 1.698
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 9.71±0.40(Predicted)
• CAS DataBase Reference: 4,5-DIHYDRO-1H-IMIDAZOLE-2-SULFONIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 4,5-DIHYDRO-1H-IMIDAZOLE-2-SULFONIC ACID(64205-92-1)
• EPA Substance Registry System: 4,5-DIHYDRO-1H-IMIDAZOLE-2-SULFONIC ACID(64205-92-1)

Safety Data

• Hazardous Substances Data: 64205-92-1(Hazardous Substances Data)

Usage

InChI:InChI=1/C3H6N2O3S/c6-9(7,8)3-4-1-2-5-3/h1-2H2,(H,4,5)(H,6,7,8)

Upstream product

• 96-45-7 N,N'-ethylenethiourea 

Downstream Products

• 51322-75-9 tizanidine 
• 1239891-55-4 C₃₉H₅₈N₄O₆ 
• 1198211-54-9 N-(2-chloro-3-fluoro-benzyl)-4,5-dihydro-1H-imidazol-2-amine 
• 1146201-99-1 N-(2,3-dichlorobenzyl)-4,5-dihydro-1H-imidazol-2-amine 
• 1071783-62-4 N-(1-(3-chlorophenyl)-2-phenylethyl)-4,5-dihydro-1H-imidazol-2-amine 
• 1173172-16-1 N-(imidazolidin-2-ylidene)-1-phenyI-2-(pyridin-4-yl)ethanamine 
• 1058720-89-0 N-(4,5-dihydro-1H-imidazol-2-yl)-1-methyl-2-phenyl-1H-indol-3-amine acetate 
• 1058720-87-8 N-(4,5-dihydro-1H-imidazol-2-yl)-2-phenyl-1H-indol-3-amine acetate 
• 1071783-53-3 N-[2-(3,5-difluorophenyl)-1-phenylethyl]-4,5-dihydro-1H-imidazol-2-amine formate 
• 214699-53-3 2-(5,6-Dihydro-7,7-Dimethyl-cyclopenta[b]pyrid-3-yl)amino-2-imidazoline 

Relevant articles and documents

Ethylenethiourea S-Oxidation Products: Preparation, Degradation, and Reaction with Proteins

Ethylenethiourea (ETU) is carcinogenic degradation product of major ethylene bis(dithiocarbamate) fungicides with biological activity attributed to poorly characterized oxidation products.The reaction of ETU with H2O2 was examined in aqueous medium at pH percent, 7, and 9 by 1H NMR spectroscopy giving five principal products: sequential formation of sulfenic, suflinic, and sulfonic acids as well as imidazoline and ethyleneurea.Maximum yields with 2 equiv of H2O2 at optimal pH were 10, 71, 5, 53, and 100percent, respectively.Oxidation proceeds mainly through the sulfinic acid to imidazoline in acidic medium and the S-oxide to ethyleneurea in basic medium. 1H NMR of urine from mice treated with ETU revealed ETU and imidazoline (no ethyleneurea or S-oxidation products).Albumin was radiolabeled in ca.17percent yield by a 10-fold excess of ETU/H2O2 oxidation products (primatily the sulfenic and sulfinic acids), and such protein modification aould be prevented by glutathione.Keywords: Ethylenethiourea; ethylenethiourea S-oxidation products; hydrogen peroxide; imidazoline; protein adducts; sulfenic acid