6425-66-7

Basic information

• Product Name: 1,2-BIS(BROMOMETHYL)-4-NITROBENZENE
• Synonyms: 1,2-BIS(BROMOMETHYL)-4-NITROBENZENE
• CAS NO: 6425-66-7
• Molecular Formula: C₈H₇Br₂NO₂
• Molecular Weight: 308.95
• Mol File: 6425-66-7.mol
• Article Data: 42

Chemical Properties

• Boiling Point: 384.562 °C at 760 mmHg
• Flash Point: 186.377 °C
• Appearance: /
• Density: 1.928 g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.645
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• CAS DataBase Reference: 1,2-BIS(BROMOMETHYL)-4-NITROBENZENE(CAS DataBase Reference)
• NIST Chemistry Reference: 1,2-BIS(BROMOMETHYL)-4-NITROBENZENE(6425-66-7)
• EPA Substance Registry System: 1,2-BIS(BROMOMETHYL)-4-NITROBENZENE(6425-66-7)

Safety Data

• Hazardous Substances Data: 6425-66-7(Hazardous Substances Data)

Usage

General Description

1,2-Bis(bromomethyl)-4-nitrobenzene is a chemical compound with the formula C8H6Br2N2O2. It is a yellow crystalline solid that is used as an intermediate in the synthesis of various organic compounds. 1,2-BIS(BROMOMETHYL)-4-NITROBENZENE is mainly used in the production of dyes, pharmaceuticals, and agrochemicals. It is also used as a reagent in organic synthesis to introduce the bromomethyl group into aromatic compounds. 1,2-Bis(bromomethyl)-4-nitrobenzene is considered a hazardous substance and should be handled with caution due to its toxic and potentially harmful effects on human health and the environment.

InChI:InChI=1/C8H7Br2NO2/c9-4-6-1-2-8(11(12)13)3-7(6)5-10/h1-3H,4-5H2

Upstream product

• 128-08-5 N-Bromosuccinimide 
• 99-51-4 4-nitro-o-xylene 
• 34241-39-9 azobisisobutyronitrile 
• 95-47-6 o-xylene 
• 91-13-4 α,α'-dibromo-o-xylene 
• 22162-19-2 (4-nitro-1,2-phenylene)dimethanol 
• 610-27-5 4-nitrophthalic acid 

Downstream Products

• 1059185-34-0 2-[5-(3,5-difluorophenyl)-3-ethyl-5-methyl-2,4-dioxoimidazolidin-1-yl]-N-[(2R)-2'-oxo-1,1',2',3-tetrahydrospiro[indene-2,3'-pyrrolo[2,3-b]pyridin]-5-yl]acetamide 
• 1033608-31-9 tert-butyl (+/-)-(2'-oxo-1'-{[2-(trimethylsilyl)ethoxy]methyl}-1,1',2',3-tetrahydrospiro[indene-2,3'-pyrrolo[2,3-b]pyridin]-5-yl)carbamate 
• 957121-34-5 tert-butyl (R)-(2'-oxo-1'-{[2-(trimethylsilyl)ethoxy]methyl}-1,1',2',3-tetrahydrospiro[indene-2,3'-pyrrolo[2,3-b]pyridin]-5-yl)carbamate 
• 957121-35-6 tert-butyl (S)-(2'-oxo-1'-{[2-(trimethylsilyl)ethoxy]methyl}-1,1',2',3-tetrahydrospiro[indene-2,3'-pyrrolo[2,3-b]pyridin]-5-yl)carbamate 
• 957130-49-3 (R)-5-amino-1,3-dihydrospiro[indene-2,3’-pyrrolo[2,3-b]pyridin]-2’(1’H)-one 
• 879132-50-0 5-amino-1‘-((2-(trimethylsilyl)ethoxy)methyl)-1,3-dihydrospiro[indene-2,3’-pyrrolo[2,3-b]pyridin]-2’(1’H)-one 
• 127168-68-7 2,3-Dihydro-5-nitro-2-(phenylmethyl)-1H-isoindole 
• 70654-85-2 5-amino-1,3-dihydrobenzo[c]thiophene 2,2-dioxide 
• 1556864-93-7 C₁₇H₁₂N₂O₃ 
• 13209-35-3 4-nitrobenzene-1,2-dicarbaldehyde 
• 879132-54-4 (+/-)-4'-chloro-5-nitro-1,3-dihydrospiro[indene-2,5'-pyrrolo[2.3-d]pyrimidin]-6'(7'H)-one 
• 1167515-34-5 C₁₂H₁₃NO₄S₂ 
• 912999-83-8 2-(2,4-dimethoxybenzyl)-5-nitro-2,3-dihydro-1H-isoindole 
• 879132-49-7 5-nitro-1‘-((2-(trimethylsilyl)ethoxy)methyl)-1,3-dihydrospiro[indene-2,3’-pyrrolo[2,3-b]pyridin]-2’(1’H)-one 

Relevant articles and documents

Substituent effects control the self-association of molecular clips in the crystalline state

We report the X-ray crystal structure of 11 molecular clips and analyze the influence of substituents (e.g., OMe, Me, and NO2) and their location on the observed crystal packing. Molecular clips 3a and 3b form tapelike structures in the crystal

THIENODIAZEPINE DERIVATIVES AND APPLICATION THEREOF

The present invention relates to a class of thienodiazepine derivatives and an application thereof in the preparation of a drug for the treatment of diseases associated with bromodomain and extra-terminal (BET) Bromodomain inhibitors. Specifically, the present invention relates to compounds represented by formulas (I) and (II), as well as pharmaceutically acceptable salts thereof.

HETEROCYCLIC SPIRO-COMPOUNDS AS AM2 RECEPTOR INHIBITORS

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