643-43-6 Usage
Chemical Properties
beige crystalline powder
Uses
2,4-Dinitrophenylacetic acid was used in the preparation of 2-hydroxy-4-nitrohenzonitrile, required for the synthesis of parabactin azide (catecholamide siderophore photoaffinity label).
General Description
Coupling of 2,4-dinitrophenylacetic acid with diazonium salts has been reported.
Purification Methods
Crystallise the acid from H2O. [Beilstein 9 IV 1691.]
Check Digit Verification of cas no
The CAS Registry Mumber 643-43-6 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 6,4 and 3 respectively; the second part has 2 digits, 4 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 643-43:
(5*6)+(4*4)+(3*3)+(2*4)+(1*3)=66
66 % 10 = 6
So 643-43-6 is a valid CAS Registry Number.
InChI:InChI=1/C8H6N2O6/c11-8(12)3-5-1-2-6(9(13)14)4-7(5)10(15)16/h1-2,4H,3H2,(H,11,12)/p-1
643-43-6Relevant articles and documents
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Martinuzzi,Vecchi
, p. 671 (1952)
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Orientation Effect of Side Chain Substituents in Aromatic Substitution. Induced Ortho Nitration
Strazzolini, Paolo,Verardo, Giancarlo,Gorassini, Fausto,Giumanini, Angelo G.
, p. 1155 - 1161 (2007/10/02)
The presence of a free carboxyl or ester function on the α-carbon of toluene induces the nitration of the phenyl ring in the ortho position at or above the statistical value (chaperon effect), when pure HNO3 is used in CH2Cl2 solution.This is at variance with the results of classical nitration in H2SO4, where p-nitration predominates by far and m-nitration occurs at a remarkable extent.The new finding is explained in terms of precomplex formation.
