643-77-6

Basic information

• Product Name: Benzeneacetic acid, a-fluoro-, ethyl ester
• CAS NO: 643-77-6
• Molecular Formula: C10H11FO2
• Molecular Weight: 182.195
• Mol File: 643-77-6.mol
• Article Data: 40

Chemical Properties

• CAS DataBase Reference: Benzeneacetic acid, a-fluoro-, ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Benzeneacetic acid, a-fluoro-, ethyl ester(643-77-6)
• EPA Substance Registry System: Benzeneacetic acid, a-fluoro-, ethyl ester(643-77-6)

Safety Data

• Hazardous Substances Data: 643-77-6(Hazardous Substances Data)

Upstream product

• 2882-19-1 ethyl 2-phenyl-2-bromoacetate 
• 31491-20-0 (1-ethoxy-2-phenylvinyloxy)trimethylsilane 
• 64-17-5 ethanol 
• 1578-63-8 d'acide 2-fluoro-2-phenyl acetique 
• 83-13-6 diethyl 2-phenylmalonate 
• 1006904-71-7 2-(dimethylamino)-1,3-dimethylimidazolidin-2-ylium trifluoromethanolate 
• 358-23-6 trifluoromethylsulfonic anhydride 
• 774-40-3 hydroxy-phenyl-acetic acid ethyl ester 
• 401-55-8 ethyl bromofluoroacetate 
• 98-80-6 phenylboronic acid 
• 3389-53-5 phenylacetylpyrrolidine 
• 108-86-1 bromobenzene 
• 401-56-9 ethyl chlorofluoroacetate 
• 3262-89-3 triphenylboroxine 

Downstream Products

• 32154-48-6 4-Fluoro-2,2-dimethyl-3-oxo-4-phenyl-butyric acid ethyl ester 
• 2802-98-4 diethyl 2-fluoro-2-phenylmalonate 
• 1126-71-2 N,N-dimethylphenethylamine 
• 14204-06-9 α-fluoro-N,N-dimethylbenzeneacetamide 
• 14204-07-0 2-fluoro-2-phenylacetamide 
• 14204-09-2 N_.N-Dimethyl-2-fluor-2-phenyl-aethylamin 
• 63818-95-1 S(+)-acide fluoro-2 phenyl-2 acetique 
• 63818-94-0 (R)-α-fluoro-α-phenylacetic acid 
• 1578-78-5 α-fluoro-α-phenylmalonic acid 
• 247039-05-0 (R_S)-(+)-2-[N-(p-toluenesulfinamido)]-3-(S)-fluoro-3-phenylpropionitrile 
• 247039-08-3 (R_S)-(-)-2-[N-(p-toluenesulfinamido)]-3-(R)-fluoro-3-phenylpropionitrile 

Relevant articles and documents

Divergent Synthesis of α-Fluorinated Carbonyl and Carboxyl Derivatives by Double Electrophilic Activation of Amides

A straightforward and divergent entry to α-fluorinated carbonyl and carboxyl derivatives is reported. Upon activation of amides with triflic anhydride and a 2-halo-pyridine and subsequent trapping of the resulting keteniminium ions with nucleophiles followed by a second electrophilic activation with NFSI and final hydrolysis, a range of amides can be transformed to α-fluorinated ketones, esters, and amides under mild conditions. Moreover, this reaction can be performed to yield enantioenriched products with a traceless chiral auxiliary.

Organo-catalyzed Michael addition of 2-fluoro-2-arylacetonitriles

An efficient synthesis of a variety of 2-arylacetonitriles containing a fluorinated stereogenic center through organo-catalyzed Michael addition reaction of 2-fluoro-2-arylacetonitriles has been developed. This protocol uses a cheap organocatalyst (DBU) and has a broad substrate scope: α, β-unsaturated ketones, esters, nitriles and sulfones were all successfully reacted. Importantly, water proved to be a good solvent for this reaction.

Synthesis of 18F-difluoromethylarenes using aryl boronic acids, ethyl bromofluoroacetate and [18F]fluoride

Herein, we report the radiosynthesis of 18F-difluoromethylarenes via the assembly of three components, a boron reagent, ethyl bromofluoroacetate, and cyclotron-produced non-carrier added [18F]fluoride. The two key steps are a copper-catalysed cross-coupling reaction, and a Mn-mediated 18F-fluorodecarboxylation.