643011-22-7

Basic information

• Product Name: β-Alanine, N-[4-[[[4-(4-chlorophenyl)-2-thiazolyl][4-(trifluoroMethyl)phenyl]aMino]Methyl]benzoyl]-
• Synonyms: β-Alanine, N-[4-[[[4-(4-chlorophenyl)-2-thiazolyl][4-(trifluoroMethyl)phenyl]aMino]Methyl]benzoyl]-;CTJDFSIKSQVUTF-UHFFFAOYSA-N
• CAS NO: 643011-22-7
• Molecular Formula: C₂₇H₂₁ClF₃N₃O₃S
• Molecular Weight: 559.9871496
• Mol File: 643011-22-7.mol
• Article Data: 2

Chemical Properties

• Appearance: /
• CAS DataBase Reference: β-Alanine, N-[4-[[[4-(4-chlorophenyl)-2-thiazolyl][4-(trifluoroMethyl)phenyl]aMino]Methyl]benzoyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: β-Alanine, N-[4-[[[4-(4-chlorophenyl)-2-thiazolyl][4-(trifluoroMethyl)phenyl]aMino]Methyl]benzoyl]-(643011-22-7)
• EPA Substance Registry System: β-Alanine, N-[4-[[[4-(4-chlorophenyl)-2-thiazolyl][4-(trifluoroMethyl)phenyl]aMino]Methyl]benzoyl]-(643011-22-7)

Safety Data

• Hazardous Substances Data: 643011-22-7(Hazardous Substances Data)

Upstream product

• 455-14-1 4-trifluoromethylphenylamine 
• 619-66-9 4-Carboxybenzaldehyde 
• 536-38-9 4-chlorobenzoylmethyl bromide 
• 199915-38-3 9-fluorenylmethoxycarbonyl isothiocyanate 

Downstream Products

• 727653-06-7 3-(4-{[[4-(4-chlorophenyl)thiazol-2-yl]-(4-trifluoromethylphenyl)amino]methyl}benzoylamino)propionic acid:tert-butylamine (1:1) 
• 727653-04-5 3-(4-{[[4-(4-chlorophenyl)thiazol-2-yl]-(4-trifluoromethylphenyl)amino]methyl}benzoylamino)propionic acid:L-histidine (1:1) 
• 727653-03-4 3-(4-{[[4-(4-chlorophenyl)thiazol-2-yl]-(4-trifluoromethylphenyl)amino]methyl}benzoylamino)propionic acid:L-lysine (1:1) 
• 727653-05-6 3-(4-{[[4-(4-chlorophenyl)thiazol-2-yl]-(4-trifluoromethylphenyl)amino]methyl}benzoylamino)propionic acid:monoethanolamine (1:1) 

Relevant articles and documents

Human glucagon receptor antagonists with thiazole cores. A novel series with superior pharmacokinetic properties

The aim of the work presented here was to design and synthesize potent human glucagon receptor antagonists with improved pharmacokinetic (PK) properties for development of pharmaceuticals for the treatment of type 2 diabetes. We describe the preparation of compounds with cyclic cores (5-aminothiazoles), their binding affinities for the human glucagon and GIP receptors, as well as affinities for rat, mouse, pig, dog, and monkey glucagon receptors. Generally, the compounds had slightly less glucagon receptor affinity compared to compounds of the previous series, but this was compensated for by much improved PK profiles in both rats and dogs with high oral bioavailabilities and sustained high plasma exposures. The compounds generally showed species selectivity for glucagon receptor binding with poor affinities for the rat, mouse, rabbit, and pig receptors. However, dog and monkey glucagon receptor affinities seem to reflect the human situation. One compound of this series, 18, was tested intravenously in an anesthetized glucagon-challenged monkey model of hyperglucagonaemia and hyperglycaemia and was shown dose-dependently to decrease glycaemia. Further, high plasma exposures and a long plasma half-life (5.2 h) were obtained.