64429-86-3 Usage
Description
D-[2-2H]GALACTOSE, also known as deuterated D-galactose, is a stable isotope-labeled compound that is a C-4 epimer of glucose. It is naturally found in milk and sugar beets, as well as being synthesized by the human body. This deuterated form of galactose has unique properties due to the presence of deuterium atoms, which can be utilized in various applications.
Uses
Used in Pharmaceutical Industry:
D-[2-2H]GALACTOSE is used as a research tool for studying the metabolism and biological processes involving galactose. The incorporation of deuterium atoms allows for the tracking and analysis of metabolic pathways, providing valuable insights into the mechanisms of action and potential therapeutic applications.
Used in Oral Therapy for Nephrotic Syndrome:
D-[2-2H]GALACTOSE is used as a potential therapeutic agent for the treatment of nephrotic syndrome in focal and segmental glomerulosclerosis. Its unique properties as a deuterated compound may offer advantages in terms of stability, bioavailability, and efficacy compared to the non-deuterated form of galactose.
Check Digit Verification of cas no
The CAS Registry Mumber 64429-86-3 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 6,4,4,2 and 9 respectively; the second part has 2 digits, 8 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 64429-86:
(7*6)+(6*4)+(5*4)+(4*2)+(3*9)+(2*8)+(1*6)=143
143 % 10 = 3
So 64429-86-3 is a valid CAS Registry Number.
64429-86-3Relevant articles and documents
Glucose is a precursor of 1-deoxynojirimycin and 1-deoxymannonojirimycin in Streptomyces subrutilus
Hardick, David J.,Hutchinson, David W.,Trew, Sally J.,Wellington, Elizabeth M. H.
, p. 6285 - 6296 (2007/10/02)
Streptomyces subrutilus ATCC 27467, when grown on a glucose-containing soyabean medium, produces both 1-deoxymannonojirimycin (DMJ) and 1-deoxynojirimycin (DNJ) in its culture medium. When 1- or 2-[2H]-D-glucose is used, the deuterium label appears at C6 in both alkaloids and the labelling pattern suggests that the first step in the biosynthesis of both DNJ and DMJ is a glucose to fructose isomerisation. Studies with 5-2H]- and 6,6-2H2-D-glucose indicate that oxidation of the 6-position of the glucose/fructose occurs during the biosynthesis and that mannonojirimycin is the first aminosugar to be formed. Mannonojirimycin can then undergo dehydration and reduction to DMJ. Alternatively, epimerisation of mannonojirimycin can occur at C2 to give nojirimycin which is then dehydrated and reduced to DNJ.
