64450-25-5

Basic information

• Product Name: 2-Butanone, 4-[(2-methylphenyl)amino]-
• CAS NO: 64450-25-5
• Molecular Formula: C11H15NO
• Molecular Weight: 177.246
• Mol File: 64450-25-5.mol
• Article Data: 10

Chemical Properties

• CAS DataBase Reference: 2-Butanone, 4-[(2-methylphenyl)amino]-(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Butanone, 4-[(2-methylphenyl)amino]-(64450-25-5)
• EPA Substance Registry System: 2-Butanone, 4-[(2-methylphenyl)amino]-(64450-25-5)

Safety Data

• Hazardous Substances Data: 64450-25-5(Hazardous Substances Data)

Upstream product

• 590-90-9 1-Hydroxy-3-butanone 
• 95-53-4 o-toluidine 
• 21911-61-5 N-(2-methylphenyl)glycine 
• 67-64-1 acetone 
• 78-94-4 methyl vinyl ketone 

Downstream Products

• 13362-80-6 4,8-dimethylquinoline 

Relevant articles and documents

Biocatalytic Aza-Michael Addition of Aromatic Amines to Enone Using α-Amylase in Water

The Michael addition of amines with enones for synthesizing β-amino carbonyls constitutes a valuable transformation in organic chemistry. While various catalyst have been made available for catalyzing the Michael addition of aromatic amines to enones but

Method for catalyzing N-alkylation reaction by TEMPO and TBN

The invention discloses a method for catalyzing N-alkylation reaction of aniline and 4-hydroxy-2-butanone by TEMPO and TBN. 4-hydroxy-2-butanone and different anilines are used as the reaction substrate, TEMPO (2,2,6,6-tetramethylpiperidine oxide) is used as catalyst, TBN (tert-butyl nitrite) is used as cocatalyst, dimethyl sulfoxide or N,N-dimethylformamide or toluene is used as solvent, N-alkylation product is obtained in nitrogen atmosphere at room temperature, no other by-products are detected. The preparation method of the invention uses TEMPO and TBN to catalyze aniline compounds and 4-hydroxy-2-butanone to perform N-alkylation reaction.

Iodine-catalyzed coupling of β-hydroxyketones with aromatic amines to form β-aminoketones and Benzo[h]quinolones

An iodine-catalyzed coupling of β-hydroxyketones with aromatic amines to yield β-aminoketones and benzo[h]quinolones had been developed. Noble metallic catalysts, oxidants, α β-unsaturated ketone intermediates and aza-Michael addition were not involved in this coupling reaction which made it unique when compared to other reactions reported in literature. Inexpensive iodine catalyst, easy accessible raw materials, mild reaction conditions, good functional group tolerance and excellent selectivity made this coupling reaction be a practical method. This reaction can also be scaled up.