64461-82-1Relevant articles and documents
Preparation method of tizanidine hydrochloride
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, (2021/07/21)
The invention discloses a preparation method of tizanidine hydrochloride, and belongs to the field of medicine preparation. According to the preparation method, 5-chloro-4-amino-2,1,3-benzothiadiazole and 1-acetyl-2-imidazolinone are taken as raw materials, and condensation, alcoholysis and salification are performed, further refining can be performed; then the tizanidine hydrochloride can be prepared. The operation is simpler, more convenient and safer, and the preparation method is more suitable for industrial production. The tizanidine hydrochloride prepared by the method is higher in yield, the obtained tizanidine hydrochloride is also higher in purity; the method has important industrial value, and can protect the supply of the bulk drug tizanidine hydrochloride and benefit the public.
Preparation method for benzothiadiazole derivative
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Paragraph 0012; 0042; 0044-0045; 0047-0048; 0050-0051; 0053, (2019/04/10)
The invention discloses a preparation method for a benzothiadiazole derivative, and specifically relates to a preparation method for tizanidine hydrochloride. The preparation method includes the following steps: (a) taking a compound II and a compound III or a salt thereof, performing reaction in an organic solvent in the presence of an acid-binding agent, and obtaining an intermediate IV throughalkalization, filtration and refining; and (b) preparing tizanidine hydrochloride shown as a formula I by taking the intermediate IV obtained by step (a) as a raw material. The method is high in yieldand purity, simple in operation, high in production efficiency, environmentally friendly, safe and suitable for industrial mass production, and has wide market application prospects. The preparationsteps are shown in the description.
Preparation method of novel central skeletal muscle relaxant
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, (2018/03/24)
The invention discloses a preparation method of a novel central skeletal muscle relaxant, and particularly relates to a preparation method of tizanidine hydrochloride. The method includes the following steps that firstly, organic acid A, a compound S1 and a compound S2 serve as raw materials react in an organic solvent X to remove a solvent, and a tizanidine organic acid salt S3 crude product is obtained; secondly, the crude product obtained in the first step is added into organic acid A and an organic solvent Y and dissolved at 50-120 DEG C; thirdly, the temperature is reduced by 50-75 DEG C,heat preservation and crystallization are kept for 2-10 hours, then the temperature is cooled again by 10-30 DEG C, heat preservation is conducted, crystallization continues for 3-10 hours, and tizanidine organic acid salt S3 is obtained; fourthly, the tizanidine organic acid salt S3 obtained in the third step serves as the raw material to prepare tizanidine hydrochloride. According to the method, the yield and purity are high, and the method is easy to operate, high in production efficiency, environmentally friendly, safe and suitable for industrial mass production and has wide market application prospects. The molecular formula is as shown in the description.