64490-92-2 Usage
Description
Sodium tolmetin dihydrate is an organic sodium salt that exists in the form of a crystalline solid. It is the dihydrate form of tolmetin sodium, which is a nonselective nonsteroidal anti-inflammatory drug (NSAID). This medication is known for its anti-inflammatory properties and is commonly used to alleviate pain, reduce inflammation, and lower fever.
Uses
Used in Pharmaceutical Industry:
Sodium tolmetin dihydrate is used as an anti-inflammatory agent for the treatment of various conditions characterized by pain, inflammation, and fever. Its application in the pharmaceutical industry is primarily due to its ability to inhibit the production of prostaglandins, which are responsible for these symptoms.
Used in Pain Management:
Sodium tolmetin dihydrate is used as a pain reliever to help manage mild to moderate pain. Its effectiveness in reducing pain is attributed to its ability to block the enzyme cyclooxygenase (COX), which is involved in the production of prostaglandins that cause pain and inflammation.
Used in Inflammation Reduction:
Sodium tolmetin dihydrate is used as an anti-inflammatory agent to reduce inflammation in various conditions, such as arthritis, tendinitis, and other musculoskeletal disorders. By inhibiting the production of prostaglandins, it helps to alleviate the swelling, redness, and discomfort associated with these conditions.
Used in Fever Reduction:
Sodium tolmetin dihydrate is used as an antipyretic to lower fever caused by various illnesses, such as infections or inflammation. Its ability to reduce the production of prostaglandins, which are involved in the regulation of body temperature, makes it an effective treatment for fever reduction.
Biological Activity
tolmetin is a non-steroidal anti-inflammatory drug that non-selectively inhibits human cox-1 and -2 [1].the cyclooxygenase (cox) is a therapeutic target for preventing cancer. two isoforms of cox have been identified: cox 1 and cox 2. cox 1 has been constitutively expressed in most tissues and involved in mediating production of prostaglandins that control normal physiological functions, such as maintenance of the gastric mucosa and regulation of renal blood flow. cox 2 is undetectable in most normal tissues [2].
in vitro
tolmetin inhibited the activity of human cox-1 and -2 with ic50 values of 0.35 and 0.82 μm, respectively [1]. tolmetin was a competitive and reversible inhibitor of prostaglandin synthetase [3].
in vivo
in rats, pretreatment with tolmetin reduced prostaglandin synthesis by minces of renal medulla. incubation of medullary tissue with tolmetin decreased prostagland production. in anesthetized dogs, tolmetin reduced renal blood flow and shifted the distribution of renal cortical flow from the inner cortex toward the outer cortex [4].
references
[1] warner t d, giuliano f, vojnovic i, et al. nonsteroid drug selectivities for cyclo-oxygenase-1 rather than cyclo-oxygenase-2 are associated with human gastrointestinal toxicity: a full in vitro analysis[j]. proceedings of the national academy of sciences, 1999, 96(13): 7563-7568.[2] dannenberg a j, altorki n k, boyle j o, et al. cyclo-oxygenase 2: a pharmacological target for the prevention of cancer[j]. the lancet oncology, 2001, 2(9): 544-551.[3] taylor r j, salata j j. inhibition of prostaglandin synthetase by tolmetin (tolectin, mcn-2559), a new non-steroidal anti-inflammatory agent[j]. biochemical pharmacology, 1976, 25(22): 2479-2484.[4] noordewier b, stygles v g, hook j b, et al. effect of tolmetin on renal function and prostaglandin metabolism[j]. journal of pharmacology and experimental therapeutics, 1978, 204(2): 461-468.
Check Digit Verification of cas no
The CAS Registry Mumber 64490-92-2 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 6,4,4,9 and 0 respectively; the second part has 2 digits, 9 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 64490-92:
(7*6)+(6*4)+(5*4)+(4*9)+(3*0)+(2*9)+(1*2)=142
142 % 10 = 2
So 64490-92-2 is a valid CAS Registry Number.
InChI:InChI=1/C15H15NO3.Na.2H2O/c1-10-3-5-11(6-4-10)15(19)13-8-7-12(16(13)2)9-14(17)18;;;/h3-8H,9H2,1-2H3,(H,17,18);;2*1H2/q;+1;;
