646-02-6Relevant articles and documents
Synthesis and collateral dilator activity of nitroxyalkylamides having direct or latent sulfhydryl moieties
Ishihara, Sadao,Saito, Fujio,Ohhata, Yasuo,Kanai, Marie,Mizuno, Hiroshi,Fujisawa, Michio,Yorikane, Ryosuke,Koike, Hiroyuki
, p. 1527 - 1530 (2003)
To develop an orally active, long-acting nitrate that does not induce tolerance, nitroxyalkyl compounds were prepared and their activities evaluated by the use of carotid collaterals in anesthetized dogs. A compound having a favorable pharmacological profile, that is, long-lasting collateral vasodilatation and little hypotension, and lack of nitrate tolerance, was chosen for further evaluation.
Synthesis of new nitroxyalkylamides as potential prototypes of hybrid nonsteroidal anti-inflammatory drugs containing NO-donating fragment
Serkov,Bezuglov
body text, p. 88 - 90 (2009/10/17)
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Study on organic nitrates. Part VII. New nitrate derivatives of 6-oxo-1,2,3,4-tetrahydro-6H-pyrimido [2,1-b] quinazoline. Potential NO donors
Korzycka
, p. 557 - 563 (2007/10/03)
A series of potential NO donors derivatives of 6-oxo-1,2,3,4-tetrahydro-6H-pyrimido[2,1-b]quinazoline with the structure of organic nitrates was obtained. They were tested in vitro potentiometrically in the reaction with sulfhydryl compound L-cysteine hydrochloride monohydrate.