64603-72-1

Basic information

• Product Name: Nicardipine Related CoMpound 2
• Synonyms: Nicardipine Related CoMpound 2
• CAS NO: 64603-72-1
• Molecular Formula: C₁₆H₁₄N₂O₆
• Molecular Weight: 330.29216
• Mol File: 64603-72-1.mol
• Article Data: 4

Chemical Properties

• Melting Point: 196-198 °C(Solv: methanol (67-56-1))
• Boiling Point: 475.2±45.0 °C(Predicted)
• Appearance: /
• Density: 1.360±0.06 g/cm3(Predicted)
• PKA: 1.05±0.25(Predicted)
• CAS DataBase Reference: Nicardipine Related CoMpound 2(CAS DataBase Reference)
• NIST Chemistry Reference: Nicardipine Related CoMpound 2(64603-72-1)
• EPA Substance Registry System: Nicardipine Related CoMpound 2(64603-72-1)

Safety Data

• Hazardous Substances Data: 64603-72-1(Hazardous Substances Data)

Usage

Uses

2,?6-?Dimethyl-?4-?(3-?nitrophenyl)?pyridine-?3,?5-?dicarboxylic acid monomethyl ester is an impurity of Nicardipine, a dihydropyridine calcium channel blocker that is used to treat high blood pressure and angina.

Upstream product

• 674-82-8 4-methyleneoxetan-2-one 
• 99-61-6 3-nitro-benzaldehyde 
• 14205-39-1 methyl (E)-3-aminocrotonate 
• 39562-70-4 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridine-dicarboxylic acid ethyl methyl ester 
• 76258-20-3 Dimethyl 2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylate 
• 74936-72-4 5-methoxycarbonyl-2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3-carboxylic acid 

Downstream Products

• 76258-21-4 2,6-dimethyl-5-methoxycarbonyl-4-(m-nitrophenyl)pyridine-3-carboxylic acid N-oxide 
• 64603-75-4 carboxymethyl methyl 2,6-dimethyl-4-(m-nitrophenyl)pyridine-3,5-dicarboxylate 
• 64603-74-3 methyl 2-methyl-4-(3-nitrophenyl)-5-oxo-5,7-dihydro-furo<3,4-b>pyridine-3-carboxylate 
• 76258-22-5 ethoxycarbonyl methyl 2,6-dimethyl-4-(m-nitrophenyl)pyridine-3,5-dicarboxylate 

Relevant articles and documents

Approaches to combinatorial synthesis of heterocycles: Solid phase synthesis of pyridines and pyrido[2,3-d]pyrimidines

An efficient solid phase synthesis of diverse pyridines and pyrido[2,3-d]pyrimidines is described. O-Immobilized keto esters 2 react with aldehydes to afford Knoevenagel derivatives 3. These undergo Hantzsch-condensation with α-oxo enamines to generate 1,4-dihydropyridines 4 that are oxidized with CAN to produce immobilized pyridines 5. The method has been extended to synthesis of fused pyrido[2,3-d]pyrimidines employing 6-aminouracils as the α-oxo enamine component. The course of the reaction on solid phase was studied by gel-phase 13C NMR spectroscopy. The synthesis is designed to be amenable for combinatorial libraries preparation.

Rapid, high-yield oxidation of Hantzsch-type 1,4-dihydropyridines with ceric ammonium nitrate

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